Carboxymethyl cellulose wafers containing antimicrobials

A modern drug delivery system for wound infections

Shiow Fern Ng, Nafisah Jumaat

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Lyophilised wafers have been shown to have potential as a modern dressing for mucosal wound healing. The wafer absorbs wound exudates and transforms into a gel, thus providing a moist environment which is essential for wound healing. The objective of this study was to develop a carboxymethyl cellulose wafer containing antimicrobials to promote wound healing and treat wound infection. The pre-formulation studies began with four polymers, sodium carboxymethyl cellulose (NaCMC), methylcellulose (MC), sodium alginate and xanthan gum, but only NaCMC and MC were chosen for further investigation. The wafers were characterised by physical assessments, solvent loss, microscopic examination, swelling and hydration properties, drug content uniformity, drug release and efficacy of antimicrobials. Three of the antimicrobials, neomycin trisulphate salt hydrate, sulphacetamide sodium and silver nitrate, were selected as model drugs. Among the formulations, NaCMC wafer containing neomycin trisulphate exhibited the most desirable wound dressing characteristics (i.e., flexibility, sponginess, uniform wafer texture, high content drug uniformity) with the highest in vitro drug release and the greatest inhibition against both Gram positive and Gram negative bacteria. In conclusion, we successfully developed a NaCMC lyophilised wafer containing antimicrobials, and this formulation has potential for use in mucosal wounds infected with bacteria.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalEuropean Journal of Pharmaceutical Sciences
Volume51
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Carboxymethylcellulose Sodium
Wound Infection
Drug Delivery Systems
Wound Healing
Methylcellulose
Neomycin
Bandages
Wounds and Injuries
Sulfacetamide
Pharmaceutical Preparations
Silver Nitrate
Exudates and Transudates
Gram-Negative Bacteria
Polymers
Salts
Gels
Sodium
Bacteria
Drug Liberation

Keywords

  • Antimicrobial dressings
  • Carboxymethyl cellulose
  • Lyophilised wafer
  • Methylcellulose
  • Wound infection

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Carboxymethyl cellulose wafers containing antimicrobials : A modern drug delivery system for wound infections. / Ng, Shiow Fern; Jumaat, Nafisah.

In: European Journal of Pharmaceutical Sciences, Vol. 51, No. 1, 2014, p. 173-179.

Research output: Contribution to journalArticle

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