Carbepenem stewardship and the impact on appropriate use and clinical outcomes

Research output: Contribution to journalArticle

Abstract

Uncontrolled and excessive use of carbapenem is associated with a higher prevalence of carbapenem resistant Pseudomonas and Acinetobacter isolates. This contributes to poor clinical outcome, a higher rate of mortality and longer hospital stay compared with infections by susceptible isolates. To address the issue of carbapenem resistance, antibiotic monitoring is implemented to reduce consumption and improve appropriate prescribing of carbapenems. The aim of this study is to evaluate whether antibiotic stewardship will be able to improve appropriate carbapenem use and improve clinical outcomes in the local setting. This is a cross-sectional observational study that compares the use of carbapenem during pre-and intervention period. Interventions were carried out by a multidisciplinary antibiotic management team. A total of 143 patients treated with carbapenem were included in this study. A significantly higher rate of overall appropriate carbapenem treatment (pre n=26/79, 40.6% vs. intervention n=48/64, 60.8%, p=0.017) and clinical cure (pre n=34/79, 43% vs. intervention n=46/64, 72%, p=0.001] was identified during the intervention period. There were no significant difference in terms of mortality rate and length of hospitalization. This study suggests that carbapenem stewardship approach is effective in ensuring appropriateness of carbapenem treatment in a tertiary hospital.

Original languageEnglish
Pages (from-to)699-704
Number of pages6
JournalResearch Journal of Pharmacy and Technology
Volume9
Issue number6
DOIs
Publication statusPublished - 2016

Fingerprint

Carbapenems
Anti-Bacterial Agents
Acinetobacter
Mortality
Pseudomonas
Tertiary Care Centers
Observational Studies
Length of Stay
Hospitalization
Cross-Sectional Studies

Keywords

  • Antibiotic
  • Carbapenem
  • Clinical outcomes
  • Stewardship

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

Carbepenem stewardship and the impact on appropriate use and clinical outcomes. / Ho, Lee Koon; Islahudin, Farida Hanim.

In: Research Journal of Pharmacy and Technology, Vol. 9, No. 6, 2016, p. 699-704.

Research output: Contribution to journalArticle

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