Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital

Siti Norbaya Masri, Sabariah Md Noor, Lailatul Akmar Mat Nor, Malina Osman, Md. Mostafizur Rahman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: Pregnant women are susceptible to vaginal colonization and infection by yeast. The purpose of the study was to determine the prevalence of Candida spp in high vaginal swabs of pregnant women and their antifungal susceptibility. Methods: High vaginal swab samples received from Serdang Hospital, Selangor, Malaysia during 2011 initially had microscopic examination, Gram-staining and fungal culture. These were finally confirmed by growth in chromogenic medium (CHROMagarCandida; Difco BBL, USA) and commercial biochemical identification kit (API 20C AUX; bioMérieux, Lyon, France). Antifungal susceptibility was performed by E-test method. Results: Out of 1163 specimens 200 (17.2%) candida spp were confirmed from high vaginal swabs of pregnant women. Candida albicans (83.5%) is the most common species detected followed by Candida glabrata (16%) and Candida famata (0.05%). All C.albicans and C.famata isolates were susceptible to fluconazole while C.glabrata isolates were dose dependent susceptibility. First and second trimester, and diabetes were considered significant factors in patients for the vaginal candidiasis (p < 0.001). Conclusions: In pregnant women, C. albicans was the frequently isolated yeast from high vaginal swabs. Routine screening and treatment are important of pregnant women regardless of symptoms.

Original languageEnglish
Pages (from-to)658-661
Number of pages4
JournalPakistan Journal of Medical Sciences
Volume31
Issue number3
DOIs
Publication statusPublished - 2015

Fingerprint

Tertiary Healthcare
Candida
Tertiary Care Centers
Pregnant Women
Candida albicans
Yeasts
Candida glabrata
Fluconazole
Candidiasis
Malaysia
Second Pregnancy Trimester
First Pregnancy Trimester
France
Staining and Labeling
Growth
Infection

Keywords

  • Candidiasis
  • Fluconazole
  • High vaginal swab
  • Pregnant women
  • Susceptibility

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital. / Masri, Siti Norbaya; Noor, Sabariah Md; Mat Nor, Lailatul Akmar; Osman, Malina; Rahman, Md. Mostafizur.

In: Pakistan Journal of Medical Sciences, Vol. 31, No. 3, 2015, p. 658-661.

Research output: Contribution to journalArticle

Masri, Siti Norbaya ; Noor, Sabariah Md ; Mat Nor, Lailatul Akmar ; Osman, Malina ; Rahman, Md. Mostafizur. / Candida isolates from pregnant women and their antifungal susceptibility in a Malaysian tertiary-care hospital. In: Pakistan Journal of Medical Sciences. 2015 ; Vol. 31, No. 3. pp. 658-661.
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AB - Objective: Pregnant women are susceptible to vaginal colonization and infection by yeast. The purpose of the study was to determine the prevalence of Candida spp in high vaginal swabs of pregnant women and their antifungal susceptibility. Methods: High vaginal swab samples received from Serdang Hospital, Selangor, Malaysia during 2011 initially had microscopic examination, Gram-staining and fungal culture. These were finally confirmed by growth in chromogenic medium (CHROMagarCandida; Difco BBL, USA) and commercial biochemical identification kit (API 20C AUX; bioMérieux, Lyon, France). Antifungal susceptibility was performed by E-test method. Results: Out of 1163 specimens 200 (17.2%) candida spp were confirmed from high vaginal swabs of pregnant women. Candida albicans (83.5%) is the most common species detected followed by Candida glabrata (16%) and Candida famata (0.05%). All C.albicans and C.famata isolates were susceptible to fluconazole while C.glabrata isolates were dose dependent susceptibility. First and second trimester, and diabetes were considered significant factors in patients for the vaginal candidiasis (p < 0.001). Conclusions: In pregnant women, C. albicans was the frequently isolated yeast from high vaginal swabs. Routine screening and treatment are important of pregnant women regardless of symptoms.

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