Cancer-Derived Exosomes as Effectors of Key Inflammation-Related Players

Norahayu Othman, Rahman Jamal, Nadiah Abu

Research output: Contribution to journalReview article

Abstract

Exosomes, a category of small lipid bilayer extracellular vesicles that are naturally secreted by many cells (both healthy and diseased), carry cargo made up of proteins, lipids, DNAs, and RNAs; all of which are functional when transferred to their recipient cells. Numerous studies have demonstrated the powerful role that exosomes play in the mediation of cell-to-cell communication to induce a pro-tumoral environment to encourage tumor progression and survival. Recently, considerable interest has developed in regard to the role that exosomes play in immunity; with studies demonstrating the ability of exosomes to either metabolically alter immune players such as dendritic cells, T cells, macrophages, and natural killer cells. In this review, we summarize the recent literature on the function of exosomes in regulating a key process that has long been associated with the progression of cancer—inflammation and immunity.

Original languageEnglish
Article number2103
JournalFrontiers in Immunology
Volume10
DOIs
Publication statusPublished - 4 Sep 2019
Externally publishedYes

Fingerprint

Exosomes
Inflammation
Neoplasms
Immunity
Lipid Bilayers
Cell Communication
Natural Killer Cells
Dendritic Cells
Macrophages
RNA
T-Lymphocytes
Lipids
DNA
Proteins

Keywords

  • cancer
  • Exosomes
  • immune molecules
  • inflammation
  • tumorigenesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Cancer-Derived Exosomes as Effectors of Key Inflammation-Related Players. / Othman, Norahayu; Jamal, Rahman; Abu, Nadiah.

In: Frontiers in Immunology, Vol. 10, 2103, 04.09.2019.

Research output: Contribution to journalReview article

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