Can we confidently diagnose pilomatricoma with fine needle aspiration cytology?

Wong Yin Ping, Noraidah Masir, Noor Akmal Sharifah

Research output: Contribution to journalArticle

Abstract

Pilomatricomas can be confidently diagnosed cytologically due to their characteristic cytomorphological features. However, these lesions are rarely encountered by cytopathologists and thus pose a diagnostic dilemma to even experienced individuals, especially when the lesions are focally sampled. We describe two cases of histologically confirmed pilomatricoma. The first case is of a 13-year-old boy with posterior cervical ‘lymphadenopathy’, and the second one is of a 12-year-old girl with a lower cheek swelling. Both aspirates comprised predominantly atypical basal-like cells, with prominent nucleoli. ‘Ghost cells’ were readily identified by cell block in case two, but cell block in case one yielded no diagnostic material. In case two, pilomatricoma was accurately diagnosed pre-operatively. A cytological suspicion of a neoplastic process was raised in case one. Despite being diagnostically challenging, pilomatricoma can be diagnosed with careful observation of two unique cytological features of the lesions: (1) pathognomonic ‘ghost cells’ and (2) irregular, saw-toothed, loosely cohesive basaloid cells, with prominent nucleoli. The role of thorough sampling of the lesion, with multiple passes of various sites, cannot be overemphasized.

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalMalaysian Journal of Medical Sciences
Volume22
Issue number1
Publication statusPublished - 2015

Fingerprint

Pilomatrixoma
Fine Needle Biopsy
Cell Biology
Neoplastic Processes
Cheek
Observation

Keywords

  • Cytology
  • Fine needle aspiration
  • Pilomatricoma
  • Skin appendage neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Can we confidently diagnose pilomatricoma with fine needle aspiration cytology? / Yin Ping, Wong; Masir, Noraidah; Sharifah, Noor Akmal.

In: Malaysian Journal of Medical Sciences, Vol. 22, No. 1, 2015, p. 84-88.

Research output: Contribution to journalArticle

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