Calixarene

A versatile material for drug design and applications

Muhammad A. Hussain, Muhammad U. Ashraf, Gulzar Muhammad, Muhammad N. Tahir, Bukhari Syed Nasir Abbas

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The therapy of various diseases by the drugs entrapped in calixarene derivatives is gaining attraction of researchers nowadays. Calixarenes are macrocyclic nano-baskets which belong to cavitands class of host-guest chemistry. They are the marvelous hosts with distinct hydrophobic three dimensional cavities to entrap and encapsulate biologically active guest drugs. Calixarene and its derivatives develop inclusion complexes with various types of drugs and vitamins for their sustained/targeted release. Calixarene and its derivatives are used as carriers for anti-cancer, anti-convulsant, anti-hypertensive, anthelmentic, anti-inflammatory, antimicrobial and antipsychotic drugs. They are the important biocompatible receptors to improve solubility, chemical reactivity and decrease cytotoxicity of poorly soluble drugs in supramolecular chemistry. This review focuses on the calixarene and its derivatives as the state-of-the-art in host-guest interactions for important drugs. We have also critically evaluated calixarenes for the development of prodrugs.

Original languageEnglish
Pages (from-to)2377-2388
Number of pages12
JournalCurrent Pharmaceutical Design
Volume23
Issue number16
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

Calixarenes
Drug Design
Pharmaceutical Preparations
Convulsants
Prodrugs
Drug Interactions
Vitamins
Solubility
Antihypertensive Agents
Antipsychotic Agents
Anti-Inflammatory Agents
Research Personnel

Keywords

  • Calixarene
  • Drug design
  • Drug release
  • Medicinal uses
  • Prodrugs
  • Supramolecular

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Calixarene : A versatile material for drug design and applications. / Hussain, Muhammad A.; Ashraf, Muhammad U.; Muhammad, Gulzar; Tahir, Muhammad N.; Syed Nasir Abbas, Bukhari.

In: Current Pharmaceutical Design, Vol. 23, No. 16, 01.01.2017, p. 2377-2388.

Research output: Contribution to journalReview article

Hussain, Muhammad A. ; Ashraf, Muhammad U. ; Muhammad, Gulzar ; Tahir, Muhammad N. ; Syed Nasir Abbas, Bukhari. / Calixarene : A versatile material for drug design and applications. In: Current Pharmaceutical Design. 2017 ; Vol. 23, No. 16. pp. 2377-2388.
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