Calcium intake, vitamin D and bone health status of post-menopausal chinese women in Kuala Lumpur

W. S S Chee, P. N. Chong, K. A. Chuah, Tilakavati Karupaiah, Norlaila Mustafa, S. Seri Suniza, Karuthan Chinna, M. N. Horcajada, L. Ameye, E. Offord-Cavin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Bone health status was investigated in 178 free-living Chinese post-menopausal women in Kuala Lumpur. Body mass index (BMI), body composition (using whole body DXA), calcium intake and serum 25-OH vitamin D status were measured along with biochemical markers of bone turnover, that is, pro-collagen Type 1 N-terminal peptide (P1NP), osteocalcin (OC) and C-telopeptide ß cross link of Type 1 collagen (CTX- β). Bone mineral density (BMD) was measured using DXA (Hologic, USA) at the lumbar spine, femoral neck and total hip. Results showed that osteopenia was present in 50% of the subjects at the spine and 57.9% at the femoral neck. Osteoporosis was diagnosed in 10% of the subjects at both the femoral neck and spine. A total of 29.3% of the subjects had high levels of CTX- ß. Mean serum level of 25-OH vitamin D was 60.4+15.6 nmol/L and 50.6% of the subjects had hypovitaminosis D (defined as <50 nmol/l). Mean total calcium intake of the subjects was 497 + 233 mg, of which only 14% met the RNI for calcium with the additional intake of calcium supplements. Body fat was also significantly correlated (r=0.181, p<0.05) with BMD at the spine but not BMD at the femoral neck. Lean body mass was positively correlated with BMD at the spine (r=0.289, p<0.001) and femoral neck (r=0.295, p<0.001). CTX-β was negatively correlated with BMD at the spine (r= -0.235, p<0.001), whereas P1NP (r=-0.215, p<0.001) and osteocalcin (r=-0.265, p<0.001) were both negatively correlated with BMD at the femoral neck. Generally, the study found that women with osteopenia had higher levels of bone turnover markers, less lean body mass and lower calcium intake than women with normal BMD. In conclusion, this study demonstrated that the majority of free living Chinese post-menopausal women in Kuala Lumpur have low calcium intake, low 25-OH vitamin D status and low bone mass and elevated biochemical markers of bone turnover.

Original languageEnglish
Pages (from-to)233-242
Number of pages10
JournalMalaysian Journal of Nutrition
Volume16
Issue number2
Publication statusPublished - 2010

Fingerprint

menopause
bone density
vitamin D
health status
Vitamin D
Femur Neck
Bone Density
Health Status
thighs
spine (bones)
bones
Spine
Calcium
calcium
Bone and Bones
Bone Remodeling
Collagen Type I
osteopenia
collagen
osteocalcin

Keywords

  • Bone health status
  • Calcium intake
  • Chinese women
  • Kuala Lumpur
  • Post-menopausal woman
  • Vitamin D

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Food Science

Cite this

Chee, W. S. S., Chong, P. N., Chuah, K. A., Karupaiah, T., Mustafa, N., Seri Suniza, S., ... Offord-Cavin, E. (2010). Calcium intake, vitamin D and bone health status of post-menopausal chinese women in Kuala Lumpur. Malaysian Journal of Nutrition, 16(2), 233-242.

Calcium intake, vitamin D and bone health status of post-menopausal chinese women in Kuala Lumpur. / Chee, W. S S; Chong, P. N.; Chuah, K. A.; Karupaiah, Tilakavati; Mustafa, Norlaila; Seri Suniza, S.; Chinna, Karuthan; Horcajada, M. N.; Ameye, L.; Offord-Cavin, E.

In: Malaysian Journal of Nutrition, Vol. 16, No. 2, 2010, p. 233-242.

Research output: Contribution to journalArticle

Chee, WSS, Chong, PN, Chuah, KA, Karupaiah, T, Mustafa, N, Seri Suniza, S, Chinna, K, Horcajada, MN, Ameye, L & Offord-Cavin, E 2010, 'Calcium intake, vitamin D and bone health status of post-menopausal chinese women in Kuala Lumpur', Malaysian Journal of Nutrition, vol. 16, no. 2, pp. 233-242.
Chee, W. S S ; Chong, P. N. ; Chuah, K. A. ; Karupaiah, Tilakavati ; Mustafa, Norlaila ; Seri Suniza, S. ; Chinna, Karuthan ; Horcajada, M. N. ; Ameye, L. ; Offord-Cavin, E. / Calcium intake, vitamin D and bone health status of post-menopausal chinese women in Kuala Lumpur. In: Malaysian Journal of Nutrition. 2010 ; Vol. 16, No. 2. pp. 233-242.
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