Brief Overview of a Decade of Genome-Wide Association Studies on Primary Hypertension

Afifah Binti Azam, Azizan Elena Aisha

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Primary hypertension is widely believed to be a complex polygenic disorder with the manifestation influenced by the interactions of genomic and environmental factors making identification of susceptibility genes a major challenge. With major advancement in high-throughput genotyping technology, genome-wide association study (GWAS) has become a powerful tool for researchers studying genetically complex diseases. GWASs work through revealing links between DNA sequence variation and a disease or trait with biomedical importance. The human genome is a very long DNA sequence which consists of billions of nucleotides arranged in a unique way. A single base-pair change in the DNA sequence is known as a single nucleotide polymorphism (SNP). With the help of modern genotyping techniques such as chip-based genotyping arrays, thousands of SNPs can be genotyped easily. Large-scale GWASs, in which more than half a million of common SNPs are genotyped and analyzed for disease association in hundreds of thousands of cases and controls, have been broadly successful in identifying SNPs associated with heart diseases, diabetes, autoimmune diseases, and psychiatric disorders. It is however still debatable whether GWAS is the best approach for hypertension. The following is a brief overview on the outcomes of a decade of GWASs on primary hypertension.

Original languageEnglish
Article number7259704
JournalInternational Journal of Endocrinology
Volume2018
DOIs
Publication statusPublished - 1 Jan 2018

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Genome-Wide Association Study
Single Nucleotide Polymorphism
Hypertension
Genotyping Techniques
Metagenomics
Human Genome
Base Pairing
Autoimmune Diseases
Psychiatry
Heart Diseases
Nucleotides
Research Personnel
Technology
Genes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

Cite this

Brief Overview of a Decade of Genome-Wide Association Studies on Primary Hypertension. / Azam, Afifah Binti; Elena Aisha, Azizan.

In: International Journal of Endocrinology, Vol. 2018, 7259704, 01.01.2018.

Research output: Contribution to journalReview article

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