Breast carcinoma Occurring from chronic granulomatous mastitis

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6 Citations (Scopus)

Abstract

Chronic granulomatous mastitis is known as a benign and relatively rare disorder that is often difficult to differentiate from breast carcinoma. We highlight the case of a 34-year-old woman who had recurrent episodes of right breast swelling and abscess for 8 years. These were proven to be chronic granulomatous mastitis by tissue biopsies on 3 different occasions. Her condition improved on similar courses of antibiotics and high-dose prednisolone. However, she subsequently developed progressive loss of vision due to an orbital tumour. She then underwent a craniotomy and left orbital decompression with excision of the tumour, which proved to be a metastatic carcinoma. A trucut biopsy of the right breast was then done and showed features consistent with an infiltrating ductal carcinoma. This case illustrates the possibility that chronic granulomatous mastitis could be a precursor for malignancy and the difficulty in differentiating one from the other. The possible mechanisms of development and the implications for future management are also discussed.

Original languageEnglish
Pages (from-to)82-85
Number of pages4
JournalMalaysian Journal of Medical Sciences
Volume19
Issue number2
Publication statusPublished - Apr 2012

Fingerprint

Granulomatous Mastitis
Breast Neoplasms
Breast
Biopsy
Neoplasms
Ductal Carcinoma
Craniotomy
Prednisolone
Decompression
Abscess
Anti-Bacterial Agents
Carcinoma

Keywords

  • Breast
  • Carcinoma
  • Disease progression
  • Granulomatous mastitis
  • Surgery

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Breast carcinoma Occurring from chronic granulomatous mastitis",
abstract = "Chronic granulomatous mastitis is known as a benign and relatively rare disorder that is often difficult to differentiate from breast carcinoma. We highlight the case of a 34-year-old woman who had recurrent episodes of right breast swelling and abscess for 8 years. These were proven to be chronic granulomatous mastitis by tissue biopsies on 3 different occasions. Her condition improved on similar courses of antibiotics and high-dose prednisolone. However, she subsequently developed progressive loss of vision due to an orbital tumour. She then underwent a craniotomy and left orbital decompression with excision of the tumour, which proved to be a metastatic carcinoma. A trucut biopsy of the right breast was then done and showed features consistent with an infiltrating ductal carcinoma. This case illustrates the possibility that chronic granulomatous mastitis could be a precursor for malignancy and the difficulty in differentiating one from the other. The possible mechanisms of development and the implications for future management are also discussed.",
keywords = "Breast, Carcinoma, Disease progression, Granulomatous mastitis, Surgery",
author = "Luqman Mazlan and {Abdullah Suhaimi}, {Shahrun Niza} and Jasmin, {Saladina Jaszle} and {Md. Latar}, {Nani Harlina} and Sellymiah Adzman and Rohaizak Muhammad",
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TY - JOUR

T1 - Breast carcinoma Occurring from chronic granulomatous mastitis

AU - Mazlan, Luqman

AU - Abdullah Suhaimi, Shahrun Niza

AU - Jasmin, Saladina Jaszle

AU - Md. Latar, Nani Harlina

AU - Adzman, Sellymiah

AU - Muhammad, Rohaizak

PY - 2012/4

Y1 - 2012/4

N2 - Chronic granulomatous mastitis is known as a benign and relatively rare disorder that is often difficult to differentiate from breast carcinoma. We highlight the case of a 34-year-old woman who had recurrent episodes of right breast swelling and abscess for 8 years. These were proven to be chronic granulomatous mastitis by tissue biopsies on 3 different occasions. Her condition improved on similar courses of antibiotics and high-dose prednisolone. However, she subsequently developed progressive loss of vision due to an orbital tumour. She then underwent a craniotomy and left orbital decompression with excision of the tumour, which proved to be a metastatic carcinoma. A trucut biopsy of the right breast was then done and showed features consistent with an infiltrating ductal carcinoma. This case illustrates the possibility that chronic granulomatous mastitis could be a precursor for malignancy and the difficulty in differentiating one from the other. The possible mechanisms of development and the implications for future management are also discussed.

AB - Chronic granulomatous mastitis is known as a benign and relatively rare disorder that is often difficult to differentiate from breast carcinoma. We highlight the case of a 34-year-old woman who had recurrent episodes of right breast swelling and abscess for 8 years. These were proven to be chronic granulomatous mastitis by tissue biopsies on 3 different occasions. Her condition improved on similar courses of antibiotics and high-dose prednisolone. However, she subsequently developed progressive loss of vision due to an orbital tumour. She then underwent a craniotomy and left orbital decompression with excision of the tumour, which proved to be a metastatic carcinoma. A trucut biopsy of the right breast was then done and showed features consistent with an infiltrating ductal carcinoma. This case illustrates the possibility that chronic granulomatous mastitis could be a precursor for malignancy and the difficulty in differentiating one from the other. The possible mechanisms of development and the implications for future management are also discussed.

KW - Breast

KW - Carcinoma

KW - Disease progression

KW - Granulomatous mastitis

KW - Surgery

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VL - 19

SP - 82

EP - 85

JO - Malaysian Journal of Medical Sciences

JF - Malaysian Journal of Medical Sciences

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