Brain functional connectivity patterns for emotional state classification in Parkinson's disease patients without dementia

R. Yuvaraj, M. Murugappan, U. Rajendra Acharya, Hojjat Adeli, Norlinah Mohamed Ibrahim, Edgar Mesquita

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Successful emotional communication is crucial for social interactions and social relationships. Parkinson's Disease (PD) patients have shown deficits in emotional recognition abilities although the research findings are inconclusive. This paper presents an investigation of six emotions (happiness, sadness, fear, anger, surprise, and disgust) of twenty non-demented (Mini-Mental State Examination score >24) PD patients and twenty Healthy Controls (HCs) using Electroencephalogram (EEG)-based Brain Functional Connectivity (BFC) patterns. The functional connectivity index feature in EEG signals is computed using three different methods: Correlation (COR), Coherence (COH), and Phase Synchronization Index (PSI). Further, a new functional connectivity index feature is proposed using bispectral analysis. The experimental results indicate that the BFC change is significantly different among emotional states of PD patients compared with HC. Also, the emotional connectivity pattern classified using Support Vector Machine (SVM) classifier yielded the highest accuracy for the new bispectral functional connectivity index. The PD patients showed emotional impairments as demonstrated by a poor classification performance. This finding suggests that decrease in the functional connectivity indices during emotional stimulation in PD, indicating functional disconnections between cortical areas.

Original languageEnglish
Pages (from-to)248-260
Number of pages13
JournalBehavioural Brain Research
Volume298
DOIs
Publication statusPublished - 1 Feb 2016

Fingerprint

Parkinson Disease
Dementia
Brain
Electroencephalography
Happiness
Aptitude
Anger
Interpersonal Relations
Fear
Emotions
Communication
Research

Keywords

  • Coherence
  • Correlation
  • EEG
  • Emotion
  • Parkinson's disease
  • PSI
  • SVM

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Brain functional connectivity patterns for emotional state classification in Parkinson's disease patients without dementia. / Yuvaraj, R.; Murugappan, M.; Acharya, U. Rajendra; Adeli, Hojjat; Mohamed Ibrahim, Norlinah; Mesquita, Edgar.

In: Behavioural Brain Research, Vol. 298, 01.02.2016, p. 248-260.

Research output: Contribution to journalArticle

Yuvaraj, R. ; Murugappan, M. ; Acharya, U. Rajendra ; Adeli, Hojjat ; Mohamed Ibrahim, Norlinah ; Mesquita, Edgar. / Brain functional connectivity patterns for emotional state classification in Parkinson's disease patients without dementia. In: Behavioural Brain Research. 2016 ; Vol. 298. pp. 248-260.
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