Brain calcification in patients with cerebral lupus

Raymond Azman Ali, A. A. Zariah, S. A. Samad, C. N. Chin, N. C T Kong

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Cerebral lupus (CL) is a common cause of morbidity and mortality in patients with SLE. The brain CTs of 27 consecutive adult patients with SLE and various neurological presentations were reviewed. The median age and duration of neurological symptoms at the time of the brain CT were 30 years (range = 14-51 years) and six days (range = 1 day-22 years), respectively. Eleven patients (41%) had normal CTs. The abnormalities in the remaining patients could be divided into six categories: (a) cerebral atrophy alone (two patients); (b) calcification alone (three patients); (c) infarct(s) alone (five patients); (d) cerebral atrophy and calcification (three patients); (e) cerebral atrophy and infarct(s) (one patient) and (f) cerebral atrophy, calcification and infarct(s) (two patients). Altogether eight patients (30%) (age range = 17-47 years) had intracerebral calcification: the globus pallidus was involved in all, putamen in two, head of the caudate nucleus in one, thalamus in one, centrum semiovale in two and cerebellum in three patients. Two patients had extensive calcifications of most of the basal ganglia, centrum semiovale and cerebellum. There was no relationship between the presence/degree of calcification and age of patients/duration or type of neurological presentation. The pathogenesis of cerebral calcification in CL is unknown. Cerebral lupus must now be included in the differential diagnosis of intracerebral calcification.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalLupus
Volume5
Issue number2
Publication statusPublished - 1996

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Brain
Atrophy
Cerebellum
Globus Pallidus
Caudate Nucleus
Putamen
Basal Ganglia
Thalamus
Differential Diagnosis
Morbidity
Mortality

Keywords

  • Calcification
  • Cerebral lupus
  • CT

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Ali, R. A., Zariah, A. A., Samad, S. A., Chin, C. N., & Kong, N. C. T. (1996). Brain calcification in patients with cerebral lupus. Lupus, 5(2), 123-128.

Brain calcification in patients with cerebral lupus. / Ali, Raymond Azman; Zariah, A. A.; Samad, S. A.; Chin, C. N.; Kong, N. C T.

In: Lupus, Vol. 5, No. 2, 1996, p. 123-128.

Research output: Contribution to journalArticle

Ali, RA, Zariah, AA, Samad, SA, Chin, CN & Kong, NCT 1996, 'Brain calcification in patients with cerebral lupus', Lupus, vol. 5, no. 2, pp. 123-128.
Ali RA, Zariah AA, Samad SA, Chin CN, Kong NCT. Brain calcification in patients with cerebral lupus. Lupus. 1996;5(2):123-128.
Ali, Raymond Azman ; Zariah, A. A. ; Samad, S. A. ; Chin, C. N. ; Kong, N. C T. / Brain calcification in patients with cerebral lupus. In: Lupus. 1996 ; Vol. 5, No. 2. pp. 123-128.
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