Bone marker and immunohistochemistry changes in toxic environments

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Osteoblast, osteoclast and osteocyte are bone cells which are affected by toxic biological and chemical agents such as endotoxins, drugs, substance abuse, chemicals in diet and metals. Bone cells produce certain proteins or chemicals when exposed to toxic condition. They can act as bone markers and could be detected with immunohistochemistry technique as reported by several studies on bone toxicity. As an example, via immunohistochemistry, endotoxins were found to elevate inflammatory cytokines: tumour necrosis factor, interleukin-1 and interleukin-6. In another study, exposure to steroids was found to increase 11β-HSD1, Dmp1 and MMP-9 expressions, while fluoride was shown to alter the expression of bone matrix metalloproteinases within the mineralising bone. Therefore, bone toxicity caused by certain agents could be demonstrated with immunohistochemistry technique. This provides a mean of detection for the prevention and treatment of bone damage induced by toxic agents.

Original languageEnglish
Title of host publicationTechnical Aspects of Toxicological Immunohistochemistry: System Specific Biomarkers
PublisherSpringer New York
Pages193-213
Number of pages21
ISBN (Electronic)9781493915163
ISBN (Print)9781493915156
DOIs
Publication statusPublished - 1 Jan 2015

Fingerprint

Poisons
immunohistochemistry
Bone
Immunohistochemistry
bones
Bone and Bones
Matrix Metalloproteinases
Endotoxins
endotoxins
Substance-Related Disorders
Toxicity
Osteocytes
substance abuse
Bone Matrix
toxicity
Biological Factors
Osteoclasts
osteoclasts
gelatinase B
osteoblasts

Keywords

  • Bone marker
  • Carbonated drinks
  • Glucocorticoid
  • Lipopolysaccharides
  • Nicotine
  • Opioids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Agricultural and Biological Sciences(all)

Cite this

Shuid, A. N., Naina Mohamed, I., Muhammad, N., Mohd Ramli, E. S., & Mohamed, N. (2015). Bone marker and immunohistochemistry changes in toxic environments. In Technical Aspects of Toxicological Immunohistochemistry: System Specific Biomarkers (pp. 193-213). Springer New York. https://doi.org/10.1007/978-1-4939-1516-3_10

Bone marker and immunohistochemistry changes in toxic environments. / Shuid, Ahmad Nazrun; Naina Mohamed, Isa; Muhammad, Norliza; Mohd Ramli, Elvy Suhana; Mohamed, Norazlina.

Technical Aspects of Toxicological Immunohistochemistry: System Specific Biomarkers. Springer New York, 2015. p. 193-213.

Research output: Chapter in Book/Report/Conference proceedingChapter

Shuid, AN, Naina Mohamed, I, Muhammad, N, Mohd Ramli, ES & Mohamed, N 2015, Bone marker and immunohistochemistry changes in toxic environments. in Technical Aspects of Toxicological Immunohistochemistry: System Specific Biomarkers. Springer New York, pp. 193-213. https://doi.org/10.1007/978-1-4939-1516-3_10
Shuid AN, Naina Mohamed I, Muhammad N, Mohd Ramli ES, Mohamed N. Bone marker and immunohistochemistry changes in toxic environments. In Technical Aspects of Toxicological Immunohistochemistry: System Specific Biomarkers. Springer New York. 2015. p. 193-213 https://doi.org/10.1007/978-1-4939-1516-3_10
Shuid, Ahmad Nazrun ; Naina Mohamed, Isa ; Muhammad, Norliza ; Mohd Ramli, Elvy Suhana ; Mohamed, Norazlina. / Bone marker and immunohistochemistry changes in toxic environments. Technical Aspects of Toxicological Immunohistochemistry: System Specific Biomarkers. Springer New York, 2015. pp. 193-213
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