Blood pressure response to injected noradrenaline in rats receiving fat-enriched diets

Ima Nirwana Soelaiman, Z. Merican, B. A K Khalid, Jamaludin Mohamed

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of feeding edible oils with different fatty acid saturation on basal and noradrenaline (NA)-induced increases in intracarotid blood pressure were studied in male normotensive rats (Rattus norwegicus). The rats were fed standard chow (C), or chow + 20% weight/weight soybean oil (SB), palm oil (PO), coconut oil (CO) or butterfat/ghee (BF), for 4 or 9 months. The basal systolic (SBP) and diastolic (DBP) blood pressures did not differ among the five groups after both feeding periods. However, after 4 months feeding, the NA-induced increases in DBP were higher in the CO and BF groups compared to C and PO groups at 1, 2 and 6 μg NA/kg body weight, and compared to PO at 3 μg NA/kg body weight. The SBP was higher in the CO and BF groups compared to PO at 1 and 3 μg NA/kg body weight, and higher in the CO group compared to PO at 4 μg NA/kg body weight. After 9 months feeding, NA-induced increases in SBP were significantly higher in the CO group compared to the C and SB groups at 3 μg NA/kg body weight. There were no significant differences between the C, SB and PO groups at any dose of NA after both feeding periods. In conclusion, PO has a beneficial effect on NA-induced increases in blood pressure of male normotensive rats as compared to CO and BF.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalAsia Pacific Journal of Pharmacology
Volume10
Issue number3-4
Publication statusPublished - 1995

Fingerprint

Norepinephrine
Fats
Diet
Blood Pressure
Soybean Oil
Body Weight
Weights and Measures
palm oil
coconut oil
Oils
Fatty Acids
Ghee

Keywords

  • blood pressure
  • butterfat
  • coconut oil
  • palm oil
  • soybean oil

ASJC Scopus subject areas

  • Pharmacology

Cite this

Blood pressure response to injected noradrenaline in rats receiving fat-enriched diets. / Soelaiman, Ima Nirwana; Merican, Z.; Khalid, B. A K; Mohamed, Jamaludin.

In: Asia Pacific Journal of Pharmacology, Vol. 10, No. 3-4, 1995, p. 79-83.

Research output: Contribution to journalArticle

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