Blood Flow-restricted Exercise Does Not Induce a Cross-Transfer of Effect: A Randomized Controlled Trial

Kwasi Ampomah, Shinichi Amano, Nathan P. Wages, Lauren Volz, Rachel Clift, Arimi Fitri Mat Ludin, Masato Nakazawa, Timothy D. Law, Todd M. Manini, James S. Thomas, David W. Russ, Brian C. Clark

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose The goal of this trial was to determine whether low-load blood flow-restricted (BFR) exercise of appendicular muscles induces a cross-transfer of effect to the trunk extensor (TE) muscles, such that low-load TE exercise would enhance TE size and function to a greater extent than standard low-load exercise in people with recurrent low back pain (LBP). We also investigated the direct effects of BFR exercise in the appendicular muscles. Methods Thirty-two adults with recurrent, nonspecific LBP were randomized into two groups: Appendicular BFR exercise (BFR exercise) or control exercise (CON exercise). All participants trained (two times per week) for 10 wk, with a 12-wk follow-up. Participants performed three sets of leg extension (LE), plantar flexion (PF), and elbow flexion (EF) exercises followed by low-load TE exercise without BFR. Outcome measures included magnetic resonance imaging-derived muscle size (quadriceps and TE), strength (LE, PF, EF, and TE), and endurance (LE and TE). Results There was no evidence for a cross-transfer of effect to the TE. There was also no statistically significant enhancement of limb skeletal muscle size or function of BFR relative to CON exercise at any time point; though, moderate effect sizes for BFR exercise were observed for enhanced muscle size and strength in the leg extensors. Conclusions Low-load BFR exercise of the appendicular muscles did not result in a cross-transfer of effect to the TE musculature. There was also no significant benefit of low-load BFR exercise on the appendicular muscle size and function, suggesting no benefit from low-load BFR exercise in adults with recurrent, nonspecific LBP.

Original languageEnglish
Pages (from-to)1817-1827
Number of pages11
JournalMedicine and Science in Sports and Exercise
Volume51
Issue number9
DOIs
Publication statusPublished - 1 Sep 2019

Fingerprint

Randomized Controlled Trials
Leg
Muscles
Low Back Pain
Elbow
Quadriceps Muscle
Muscle Strength
Blood Group Antigens
Skeletal Muscle
Extremities
Magnetic Resonance Imaging
Outcome Assessment (Health Care)

Keywords

  • KAATSU
  • MUSCLE MASS
  • MUSCLE STRENGTH
  • TRUNK EXTENSOR

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Blood Flow-restricted Exercise Does Not Induce a Cross-Transfer of Effect : A Randomized Controlled Trial. / Ampomah, Kwasi; Amano, Shinichi; Wages, Nathan P.; Volz, Lauren; Clift, Rachel; Mat Ludin, Arimi Fitri; Nakazawa, Masato; Law, Timothy D.; Manini, Todd M.; Thomas, James S.; Russ, David W.; Clark, Brian C.

In: Medicine and Science in Sports and Exercise, Vol. 51, No. 9, 01.09.2019, p. 1817-1827.

Research output: Contribution to journalArticle

Ampomah, K, Amano, S, Wages, NP, Volz, L, Clift, R, Mat Ludin, AF, Nakazawa, M, Law, TD, Manini, TM, Thomas, JS, Russ, DW & Clark, BC 2019, 'Blood Flow-restricted Exercise Does Not Induce a Cross-Transfer of Effect: A Randomized Controlled Trial', Medicine and Science in Sports and Exercise, vol. 51, no. 9, pp. 1817-1827. https://doi.org/10.1249/MSS.0000000000001984
Ampomah, Kwasi ; Amano, Shinichi ; Wages, Nathan P. ; Volz, Lauren ; Clift, Rachel ; Mat Ludin, Arimi Fitri ; Nakazawa, Masato ; Law, Timothy D. ; Manini, Todd M. ; Thomas, James S. ; Russ, David W. ; Clark, Brian C. / Blood Flow-restricted Exercise Does Not Induce a Cross-Transfer of Effect : A Randomized Controlled Trial. In: Medicine and Science in Sports and Exercise. 2019 ; Vol. 51, No. 9. pp. 1817-1827.
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AU - Mat Ludin, Arimi Fitri

AU - Nakazawa, Masato

AU - Law, Timothy D.

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N2 - Purpose The goal of this trial was to determine whether low-load blood flow-restricted (BFR) exercise of appendicular muscles induces a cross-transfer of effect to the trunk extensor (TE) muscles, such that low-load TE exercise would enhance TE size and function to a greater extent than standard low-load exercise in people with recurrent low back pain (LBP). We also investigated the direct effects of BFR exercise in the appendicular muscles. Methods Thirty-two adults with recurrent, nonspecific LBP were randomized into two groups: Appendicular BFR exercise (BFR exercise) or control exercise (CON exercise). All participants trained (two times per week) for 10 wk, with a 12-wk follow-up. Participants performed three sets of leg extension (LE), plantar flexion (PF), and elbow flexion (EF) exercises followed by low-load TE exercise without BFR. Outcome measures included magnetic resonance imaging-derived muscle size (quadriceps and TE), strength (LE, PF, EF, and TE), and endurance (LE and TE). Results There was no evidence for a cross-transfer of effect to the TE. There was also no statistically significant enhancement of limb skeletal muscle size or function of BFR relative to CON exercise at any time point; though, moderate effect sizes for BFR exercise were observed for enhanced muscle size and strength in the leg extensors. Conclusions Low-load BFR exercise of the appendicular muscles did not result in a cross-transfer of effect to the TE musculature. There was also no significant benefit of low-load BFR exercise on the appendicular muscle size and function, suggesting no benefit from low-load BFR exercise in adults with recurrent, nonspecific LBP.

AB - Purpose The goal of this trial was to determine whether low-load blood flow-restricted (BFR) exercise of appendicular muscles induces a cross-transfer of effect to the trunk extensor (TE) muscles, such that low-load TE exercise would enhance TE size and function to a greater extent than standard low-load exercise in people with recurrent low back pain (LBP). We also investigated the direct effects of BFR exercise in the appendicular muscles. Methods Thirty-two adults with recurrent, nonspecific LBP were randomized into two groups: Appendicular BFR exercise (BFR exercise) or control exercise (CON exercise). All participants trained (two times per week) for 10 wk, with a 12-wk follow-up. Participants performed three sets of leg extension (LE), plantar flexion (PF), and elbow flexion (EF) exercises followed by low-load TE exercise without BFR. Outcome measures included magnetic resonance imaging-derived muscle size (quadriceps and TE), strength (LE, PF, EF, and TE), and endurance (LE and TE). Results There was no evidence for a cross-transfer of effect to the TE. There was also no statistically significant enhancement of limb skeletal muscle size or function of BFR relative to CON exercise at any time point; though, moderate effect sizes for BFR exercise were observed for enhanced muscle size and strength in the leg extensors. Conclusions Low-load BFR exercise of the appendicular muscles did not result in a cross-transfer of effect to the TE musculature. There was also no significant benefit of low-load BFR exercise on the appendicular muscle size and function, suggesting no benefit from low-load BFR exercise in adults with recurrent, nonspecific LBP.

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