Blood fatty acid status and clinical outcomes in dialysis patients

A systematic review

Ban Hock Khor, Sreelakshmi Sankara Narayanan, Karuthan Chinna, Abdul Halim Abdul Gafor, Zulfitri Azuan Mat Daud, Pramod Khosla, Kalyana Sundram, Tilakavati Karupaiah

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onwards, reporting FA profile in hemodialysis and peritoneal DP, were identified from PubMed, Embase, and the Cochrane library. Studies on pediatric, predialysis chronic kidney disease, acute kidney injury, and transplant patients were excluded. Moderate to high levels of n-3 polyunsaturated fatty acids (PUFA) were reported in Japan, Korea, Denmark, and Sweden. Compared to healthy adults, DP had lower proportions of n-3 and n-6 PUFA, but higher proportion of monounsaturated fatty acids. Two studies reported inverse associations between n-3 PUFAs and risks of sudden cardiac death, while one reported eicosapentaenoic acid + docosahexaenoic acid)/arachidonic acid ratio was inversely associated with cardiovascular events. The relationship between all-cause mortality and blood FA composition in DP remained inconclusive. The current evidence highlights a critical role for essential FA in nutritional management of DP.

Original languageEnglish
Article number1353
JournalNutrients
Volume10
Issue number10
DOIs
Publication statusPublished - 1 Oct 2018

Fingerprint

systematic review
dialysis
Dialysis
Fatty Acids
fatty acids
blood
fatty acid composition
Omega-3 Fatty Acids
polyunsaturated fatty acids
kidneys
Monounsaturated Fatty Acids
Essential Fatty Acids
hemodialysis
Eicosapentaenoic Acid
Docosahexaenoic Acids
Sudden Cardiac Death
omega-6 fatty acids
Peritoneal Dialysis
essential fatty acids
Feeding Behavior

Keywords

  • Blood fatty acid
  • Cardiovascular disease
  • Dialysis
  • Essential fatty acid
  • Fatty acid composition
  • Hemodialysis
  • N-3 polyunsaturated fatty acids
  • Peritoneal dialysis
  • Systematic review

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Blood fatty acid status and clinical outcomes in dialysis patients : A systematic review. / Khor, Ban Hock; Narayanan, Sreelakshmi Sankara; Chinna, Karuthan; Abdul Gafor, Abdul Halim; Daud, Zulfitri Azuan Mat; Khosla, Pramod; Sundram, Kalyana; Karupaiah, Tilakavati.

In: Nutrients, Vol. 10, No. 10, 1353, 01.10.2018.

Research output: Contribution to journalReview article

Khor, Ban Hock ; Narayanan, Sreelakshmi Sankara ; Chinna, Karuthan ; Abdul Gafor, Abdul Halim ; Daud, Zulfitri Azuan Mat ; Khosla, Pramod ; Sundram, Kalyana ; Karupaiah, Tilakavati. / Blood fatty acid status and clinical outcomes in dialysis patients : A systematic review. In: Nutrients. 2018 ; Vol. 10, No. 10.
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