Profil Darah dan Urin Tikus Teraruh Hipertensi yang diberi Suplemen Puri Jambu Batu Merah (Psidium guajava)

Translated title of the contribution: Blood and urine profiles of spontaneous hypertensive rats supplemented with pink guava (Psidium guajava) puree

M. D Nor Norazmir, Mohd Yatim Ayub, Said Mamot

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    The objectives of this study were to investigate the effects of pink guava (Psidium guajava) puree on blood and urine profiles of Spontaneous Hypertensive Rats (SHR). Twenty-four male SHR rats were divided into four groups (control, CG (distilled water); low dosage group, LDG (0.5 g/kg body weight); medium dosage group, MDG (1.0 glkg body weight); and high dosage group, HDG (2.0g/kg body weight)). The rats were given pink guava puree via force-feeding and fed ad libitum for 28 days in individual cages. Organ weights and serum lipid profiles were not significantly different between the groups. Blood glucose value (mmol/l)for MDG (5.53±0.69) was significantly higher than CG (453±039) and LDG (4.80±054). Blood chemistry analysis showed no significant difference in total antioxidant status, urea, alkaline phosphate and globulin between the groups. There were significant differences in the blood hematology, concentrations total bilirubin, gamma-glutamyl transpeptidase (GGT), total protein, albumin and albumin.-globulin ratio between CG and treated groups. LDG's red blood cell (10.95±057 × 1012/l) and platelet (941.17±139.0 × 109/l) were higher compared to CG (10.05±0.63 × 1012/l) 858.83±163. 4×109/l) respectively. LDG (3.51 umol/l) had lower total bilirubin concentration than CG (4.25 umol/l). GGT level was significantly higher in HDG (8.67 U/l) compared to CG and MDG (7.00 U/l). Albumin.-globulin ratio values were significantly lower in CG(150) than MDG (136) and HDG (137). In conclusion, this study shows pink guava (Psidium guajava) puree supplementation did not have significant effects on serum lipid and urine profiles, organ weight and blood glucose concentration of SHR.

    Original languageUndefined/Unknown
    Pages (from-to)929-934
    Number of pages6
    JournalSains Malaysiana
    Volume38
    Issue number6
    Publication statusPublished - Oct 2009

    Fingerprint

    Psidium
    Urine
    Globulins
    Albumins
    Organ Size
    gamma-Glutamyltransferase
    Body Weight
    Bilirubin
    Blood Glucose
    Lipids
    Enteral Nutrition
    Hematology
    Serum
    Urea
    Blood Platelets
    Antioxidants
    Erythrocytes
    Phosphates
    Control Groups
    Water

    Keywords

    • Blood profile
    • Pink guava
    • Spontaneous hypertensive rats
    • Urine profile

    ASJC Scopus subject areas

    • General

    Cite this

    Profil Darah dan Urin Tikus Teraruh Hipertensi yang diberi Suplemen Puri Jambu Batu Merah (Psidium guajava). / Norazmir, M. D Nor; Ayub, Mohd Yatim; Mamot, Said.

    In: Sains Malaysiana, Vol. 38, No. 6, 10.2009, p. 929-934.

    Research output: Contribution to journalArticle

    Norazmir, M. D Nor ; Ayub, Mohd Yatim ; Mamot, Said. / Profil Darah dan Urin Tikus Teraruh Hipertensi yang diberi Suplemen Puri Jambu Batu Merah (Psidium guajava). In: Sains Malaysiana. 2009 ; Vol. 38, No. 6. pp. 929-934.
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    abstract = "The objectives of this study were to investigate the effects of pink guava (Psidium guajava) puree on blood and urine profiles of Spontaneous Hypertensive Rats (SHR). Twenty-four male SHR rats were divided into four groups (control, CG (distilled water); low dosage group, LDG (0.5 g/kg body weight); medium dosage group, MDG (1.0 glkg body weight); and high dosage group, HDG (2.0g/kg body weight)). The rats were given pink guava puree via force-feeding and fed ad libitum for 28 days in individual cages. Organ weights and serum lipid profiles were not significantly different between the groups. Blood glucose value (mmol/l)for MDG (5.53±0.69) was significantly higher than CG (453±039) and LDG (4.80±054). Blood chemistry analysis showed no significant difference in total antioxidant status, urea, alkaline phosphate and globulin between the groups. There were significant differences in the blood hematology, concentrations total bilirubin, gamma-glutamyl transpeptidase (GGT), total protein, albumin and albumin.-globulin ratio between CG and treated groups. LDG's red blood cell (10.95±057 × 1012/l) and platelet (941.17±139.0 × 109/l) were higher compared to CG (10.05±0.63 × 1012/l) 858.83±163. 4×109/l) respectively. LDG (3.51 umol/l) had lower total bilirubin concentration than CG (4.25 umol/l). GGT level was significantly higher in HDG (8.67 U/l) compared to CG and MDG (7.00 U/l). Albumin.-globulin ratio values were significantly lower in CG(150) than MDG (136) and HDG (137). In conclusion, this study shows pink guava (Psidium guajava) puree supplementation did not have significant effects on serum lipid and urine profiles, organ weight and blood glucose concentration of SHR.",
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    AU - Mamot, Said

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    AB - The objectives of this study were to investigate the effects of pink guava (Psidium guajava) puree on blood and urine profiles of Spontaneous Hypertensive Rats (SHR). Twenty-four male SHR rats were divided into four groups (control, CG (distilled water); low dosage group, LDG (0.5 g/kg body weight); medium dosage group, MDG (1.0 glkg body weight); and high dosage group, HDG (2.0g/kg body weight)). The rats were given pink guava puree via force-feeding and fed ad libitum for 28 days in individual cages. Organ weights and serum lipid profiles were not significantly different between the groups. Blood glucose value (mmol/l)for MDG (5.53±0.69) was significantly higher than CG (453±039) and LDG (4.80±054). Blood chemistry analysis showed no significant difference in total antioxidant status, urea, alkaline phosphate and globulin between the groups. There were significant differences in the blood hematology, concentrations total bilirubin, gamma-glutamyl transpeptidase (GGT), total protein, albumin and albumin.-globulin ratio between CG and treated groups. LDG's red blood cell (10.95±057 × 1012/l) and platelet (941.17±139.0 × 109/l) were higher compared to CG (10.05±0.63 × 1012/l) 858.83±163. 4×109/l) respectively. LDG (3.51 umol/l) had lower total bilirubin concentration than CG (4.25 umol/l). GGT level was significantly higher in HDG (8.67 U/l) compared to CG and MDG (7.00 U/l). Albumin.-globulin ratio values were significantly lower in CG(150) than MDG (136) and HDG (137). In conclusion, this study shows pink guava (Psidium guajava) puree supplementation did not have significant effects on serum lipid and urine profiles, organ weight and blood glucose concentration of SHR.

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    KW - Urine profile

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