Biotransformation of nitrofurans antibiotics by aspergillus species-residual antibacterial activity

Nur Syahira Mohammad, Muhd Fauzi Safian, Shahrul Hisham Zainal Ariffin, Zaidah Zainal Ariffin

Research output: Contribution to journalArticle

Abstract

Nitrofurans antibiotics are banned drug. Nitrofurans antibiotics that administered to the animalwill be excreted out in parent or metabolite through faeces. The excretion causes soilcontamination and also the emerging of bacteria that resistant the nitrofurans antibiotics. Theaim of this study is to isolate potential soil fungi species that able to degrade nitrofuransantibiotics and determine the antibacterial activity of the nitrofurans antibiotic residues. Ninedifferent colonies were successfully identified using molecular tools, polymerase chainreactions. ITS 1 (forward) and ITS 4 (reverse) primer were used in this study. A total of sixspecies from Aspergillus namely Aspergillus sydowii strain SCAU066, Aspergillus tamariiisolate TN-7, Aspergillus candidus strain KUFA 0062, Aspergillus versicolor isolate BAB-6580, Aspergillus protuberus strain KAS 6024 and the rest are Cephaliophora tropica strainxsd08001 and Lichtheimia ramosa strain R and two species from Penicillium which arePenicillium citrinum strain FIB SR4 and Penicillium citrinum isolate J33. Growth curve ofAspergillus species was plotted, most fungi showed exponential phase from day 2 to day 6.Aspergillus species were used in degrading nitrofurans antibiotics furaltadone, furazolidone andnitrofurazone. This study showed Aspergillus tamarii efficiently degraded 12-30 % ofnitrofurans antibiotics after 96 h of incubation. Thus the isolated soil fungi, Aspergillus tamariishowed the ability to degrade nitrofurans antibiotics.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalMalaysian Journal of Biochemistry and Molecular Biology
Volume21
Issue number2
Publication statusPublished - 1 Aug 2018

Fingerprint

Nitrofurans
Aspergillus
Biotransformation
Anti-Bacterial Agents
Fungi
Penicillium
Soil
Furazolidone
Soils
Metabolites
Feces
Bacteria

Keywords

  • Aspergillus species
  • Furaltadone
  • Furazolidone
  • Nitrofurans residues
  • Nitrofurazone
  • Soil fungi

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Biotransformation of nitrofurans antibiotics by aspergillus species-residual antibacterial activity. / Mohammad, Nur Syahira; Safian, Muhd Fauzi; Zainal Ariffin, Shahrul Hisham; Ariffin, Zaidah Zainal.

In: Malaysian Journal of Biochemistry and Molecular Biology, Vol. 21, No. 2, 01.08.2018, p. 28-33.

Research output: Contribution to journalArticle

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