Biomechanical properties of bone cement with addition of cefuroxime antibiotic

D. Mohd Fuad, O. Masbah, Y. Shahril, Jamari Sapuan, Nor Hamdan Mohamad Yahaya, Sahrim Ahmad

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Antibiotic-loaded bone cement has been used as prophylaxis against infection in total joint replacement surgery. Its effect on the mechanical strength of cement is a major concern as high dose of antibiotic was associated with a significant reduction in mechanical strength of bone cement. However, the cut-off antibiotic that weakens the mechanical strength of cement remains to be determined. This study was undertaken to observe the changes in the mechanical properties of bone cement with gradual increments of Cefuroxime antibiotic, Cefuroxime at different doses; 0, 1.5, 3.0 and 4.5gm were added to a packet of 40gm bone cement (Simplex P) and study samples were prepared by using third generation cementing technique. Mechanical impact, flexural and tensile strength were tested on each sample. Significant impact and tensile strength reduction were observed after addition of 4.5gm of Cefuroxime. However, flexural strength was significantly reduced at a lower dose of 3.0gm. The maximum dose of Cefuroxime to be safely added to 40mg Surgical Simplex P is 1.5gm when third generation cementing technique is used. Further study is needed to determine whether it is an effective dose as regards to microbiological parameters.

Original languageEnglish
Pages (from-to)27-29
Number of pages3
JournalMedical Journal of Malaysia
Volume61
Issue numberSUPPL. A
Publication statusPublished - Feb 2006

Fingerprint

Cefuroxime
Bone Cements
Methylmethacrylate
Anti-Bacterial Agents
Tensile Strength
Replacement Arthroplasties
Infection

Keywords

  • Antibiotic
  • Bone cement
  • Mechanical strength

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Biomechanical properties of bone cement with addition of cefuroxime antibiotic. / Fuad, D. Mohd; Masbah, O.; Shahril, Y.; Sapuan, Jamari; Mohamad Yahaya, Nor Hamdan; Ahmad, Sahrim.

In: Medical Journal of Malaysia, Vol. 61, No. SUPPL. A, 02.2006, p. 27-29.

Research output: Contribution to journalArticle

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