Biological activity studies of Ancistrocladus tectorius

Ikram M. Said, Ishak Ahmad, M. D. Yahya, A. M. Marini

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Methanol (ATRM) and chloroform (alkaloidal) extracts (ATRC) from the roots of Ancistrocladus tectorius Merr. were used for in vitro biological tests including antibacterial (eleven species or isolates), antiviral (HSV type 1), antiparasitic (Giardia lamblia), effects on the phagocytic and cytotoxic functions of murine macrophages as well as toxicities toward brine shrimp and cell cultures (nine types). The antibacterial, antiviral and toxic activities were moderate, while anti-giardial activity was not observed. Phagocytosis and intracellular killing of Listeria monocytogenes was increased by both extracts. However, antibody-dependent cell-mediated cytotoxicity (ADCC) of antibody-opsonised sheep red blood cells was increased by the methanol extract but inhibited by the chloroform extract.

Original languageEnglish
Pages (from-to)357-363
Number of pages7
JournalPharmaceutical Biology
Volume39
Issue number5
DOIs
Publication statusPublished - 2001

Fingerprint

Chloroform
Bioactivity
Antiviral Agents
Methanol
bioactive properties
Listeria
Antibody-Dependent Cell Cytotoxicity
Artemia
Antiparasitic Agents
Giardia lamblia
Antibodies
Macrophages
Poisons
extracts
Human Herpesvirus 1
Listeria monocytogenes
Cytotoxicity
Phagocytosis
Cell culture
chloroform

Keywords

  • Ancistrocladus tectorius
  • Antibacteria
  • Antiparasite
  • Antivirus
  • Cytotoxicity
  • Macrophages
  • Malaysia
  • Medicinal plants

ASJC Scopus subject areas

  • Plant Science
  • Medical Laboratory Technology
  • Clinical Biochemistry
  • Pharmacology

Cite this

Biological activity studies of Ancistrocladus tectorius. / Said, Ikram M.; Ahmad, Ishak; Yahya, M. D.; Marini, A. M.

In: Pharmaceutical Biology, Vol. 39, No. 5, 2001, p. 357-363.

Research output: Contribution to journalArticle

Said, Ikram M. ; Ahmad, Ishak ; Yahya, M. D. ; Marini, A. M. / Biological activity studies of Ancistrocladus tectorius. In: Pharmaceutical Biology. 2001 ; Vol. 39, No. 5. pp. 357-363.
@article{134bf5e946534a46b0e39a67991fd3b6,
title = "Biological activity studies of Ancistrocladus tectorius",
abstract = "Methanol (ATRM) and chloroform (alkaloidal) extracts (ATRC) from the roots of Ancistrocladus tectorius Merr. were used for in vitro biological tests including antibacterial (eleven species or isolates), antiviral (HSV type 1), antiparasitic (Giardia lamblia), effects on the phagocytic and cytotoxic functions of murine macrophages as well as toxicities toward brine shrimp and cell cultures (nine types). The antibacterial, antiviral and toxic activities were moderate, while anti-giardial activity was not observed. Phagocytosis and intracellular killing of Listeria monocytogenes was increased by both extracts. However, antibody-dependent cell-mediated cytotoxicity (ADCC) of antibody-opsonised sheep red blood cells was increased by the methanol extract but inhibited by the chloroform extract.",
keywords = "Ancistrocladus tectorius, Antibacteria, Antiparasite, Antivirus, Cytotoxicity, Macrophages, Malaysia, Medicinal plants",
author = "Said, {Ikram M.} and Ishak Ahmad and Yahya, {M. D.} and Marini, {A. M.}",
year = "2001",
doi = "10.1076/phbi.39.5.357.5897",
language = "English",
volume = "39",
pages = "357--363",
journal = "Pharmaceutical Biology",
issn = "1388-0209",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - Biological activity studies of Ancistrocladus tectorius

AU - Said, Ikram M.

AU - Ahmad, Ishak

AU - Yahya, M. D.

AU - Marini, A. M.

PY - 2001

Y1 - 2001

N2 - Methanol (ATRM) and chloroform (alkaloidal) extracts (ATRC) from the roots of Ancistrocladus tectorius Merr. were used for in vitro biological tests including antibacterial (eleven species or isolates), antiviral (HSV type 1), antiparasitic (Giardia lamblia), effects on the phagocytic and cytotoxic functions of murine macrophages as well as toxicities toward brine shrimp and cell cultures (nine types). The antibacterial, antiviral and toxic activities were moderate, while anti-giardial activity was not observed. Phagocytosis and intracellular killing of Listeria monocytogenes was increased by both extracts. However, antibody-dependent cell-mediated cytotoxicity (ADCC) of antibody-opsonised sheep red blood cells was increased by the methanol extract but inhibited by the chloroform extract.

AB - Methanol (ATRM) and chloroform (alkaloidal) extracts (ATRC) from the roots of Ancistrocladus tectorius Merr. were used for in vitro biological tests including antibacterial (eleven species or isolates), antiviral (HSV type 1), antiparasitic (Giardia lamblia), effects on the phagocytic and cytotoxic functions of murine macrophages as well as toxicities toward brine shrimp and cell cultures (nine types). The antibacterial, antiviral and toxic activities were moderate, while anti-giardial activity was not observed. Phagocytosis and intracellular killing of Listeria monocytogenes was increased by both extracts. However, antibody-dependent cell-mediated cytotoxicity (ADCC) of antibody-opsonised sheep red blood cells was increased by the methanol extract but inhibited by the chloroform extract.

KW - Ancistrocladus tectorius

KW - Antibacteria

KW - Antiparasite

KW - Antivirus

KW - Cytotoxicity

KW - Macrophages

KW - Malaysia

KW - Medicinal plants

UR - http://www.scopus.com/inward/record.url?scp=0035728611&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035728611&partnerID=8YFLogxK

U2 - 10.1076/phbi.39.5.357.5897

DO - 10.1076/phbi.39.5.357.5897

M3 - Article

AN - SCOPUS:0035728611

VL - 39

SP - 357

EP - 363

JO - Pharmaceutical Biology

JF - Pharmaceutical Biology

SN - 1388-0209

IS - 5

ER -