Bioactive phenylethanoids and coumarines from basalmocitrus cameroonensis

Jean Duplex Wansi, Judith Liliane Djouaka Bavoua, Emmanuel Ngeufa Happi, Krishna Prasad Devkota, Bruno Ndjakou Lenta, Osman Mesaik Mohammed Ahmed Hassan, Muhammad Iqbal Choudhary, Zacharias Tanee Fomum, Norbert Sewald

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Two new phenylethanoids, basalefhanoid A (1) and B (2), and one new ceramide, basalamide A (3), together with eleven known compounds (4-14) were isolated from the MeOH extract of the stem barks of Basalmocitrus cameroonensis. The structures of all compounds were determined by comprehensive analyses of their ID and 2D NMR, mass spectral (EI and ESI) data, chemical reactions, and comparison with previously known analogs. Compounds 1, 2, 5, and 7-10 demonstrated a strong inhibition on reactive oxygen species (ROS) production in the oxidative burst activity of whole blood on activation with serum opsonized zymosan in the range of IC50 = 0.06- 12.30 μg mL -1.

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Volume64
Issue number4
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Coumarins
Zymosan
Ceramides
Chemical reactions
Reactive Oxygen Species
Blood
Chemical activation
Nuclear magnetic resonance

Keywords

  • Basalmocitrus cameroonensi
  • Ceramide
  • Oxidative burst inhibition
  • Phenylethanoid
  • Rutaceae

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Wansi, J. D., Djouaka Bavoua, J. L., Happi, E. N., Devkota, K. P., Lenta, B. N., Mohammed Ahmed Hassan, O. M., ... Sewald, N. (2009). Bioactive phenylethanoids and coumarines from basalmocitrus cameroonensis. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 64(4), 452-458.

Bioactive phenylethanoids and coumarines from basalmocitrus cameroonensis. / Wansi, Jean Duplex; Djouaka Bavoua, Judith Liliane; Happi, Emmanuel Ngeufa; Devkota, Krishna Prasad; Lenta, Bruno Ndjakou; Mohammed Ahmed Hassan, Osman Mesaik; Choudhary, Muhammad Iqbal; Fomum, Zacharias Tanee; Sewald, Norbert.

In: Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, Vol. 64, No. 4, 2009, p. 452-458.

Research output: Contribution to journalArticle

Wansi, JD, Djouaka Bavoua, JL, Happi, EN, Devkota, KP, Lenta, BN, Mohammed Ahmed Hassan, OM, Choudhary, MI, Fomum, ZT & Sewald, N 2009, 'Bioactive phenylethanoids and coumarines from basalmocitrus cameroonensis', Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, vol. 64, no. 4, pp. 452-458.
Wansi, Jean Duplex ; Djouaka Bavoua, Judith Liliane ; Happi, Emmanuel Ngeufa ; Devkota, Krishna Prasad ; Lenta, Bruno Ndjakou ; Mohammed Ahmed Hassan, Osman Mesaik ; Choudhary, Muhammad Iqbal ; Fomum, Zacharias Tanee ; Sewald, Norbert. / Bioactive phenylethanoids and coumarines from basalmocitrus cameroonensis. In: Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences. 2009 ; Vol. 64, No. 4. pp. 452-458.
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