Betanodavirus: Dissection of the viral life cycle

Low Chen Fei, Syarul Nataqain Baharum, H. Y. Chee, M. Z.H. Rozaini, M. Najiah

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Progressive research has been recently made in dissecting the molecular biology of Betanodavirus life cycle, the causative pathogen of viral encephalopathy and retinopathy in economic important marine fish species. Establishment of betanodavirus infectious clone allows the manipulation of virus genome for functional genomic study, which elucidates the biological event of the viral life cycle at molecular level. The betanodavirus strategizes its replication by expressing anti-apoptosis/antinecrotic proteins to maintain the cell viability during early infection. Subsequently utilizes and controls the biological machinery of the infected cells for viral genome replication. Towards the late phase of infection, mass production of capsid protein for virion assembly induces the activation of host apoptosis pathway. It eventually leads to the cell lysis and death, which the lysis of cell contributes to the accomplishment of viral shedding that completes a viral life cycle. The recent efforts to dissect the entire betanodavirus life cycle are currently reviewed.

Original languageEnglish
JournalJournal of Fish Diseases
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Nodaviridae
Betanodavirus
dissection
Life Cycle Stages
Dissection
life cycle (organisms)
life cycle
lysis
apoptosis
genome
Apoptosis
Virus Shedding
retinal diseases
encephalopathy
viral shedding
protein
Viral Genome
Capsid Proteins
Brain Diseases
cells

Keywords

  • Betanodavirus
  • Virus attachment and entry
  • Virus encapsidation and shedding
  • Virus life cycle
  • Virus replication

ASJC Scopus subject areas

  • Aquatic Science
  • veterinary (miscalleneous)

Cite this

Betanodavirus : Dissection of the viral life cycle. / Chen Fei, Low; Baharum, Syarul Nataqain; Chee, H. Y.; Rozaini, M. Z.H.; Najiah, M.

In: Journal of Fish Diseases, 2017.

Research output: Contribution to journalArticle

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