Benzophenones and xanthones from Garcinia cantleyana var. cantleyana and their inhibitory activities on human low-density lipoprotein oxidation and platelet aggregation

Ibrahim Jantan, Fadlina Chany Saputri

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Three benzophenones, 2,6,3′,5′-tetrahydroxybenzophenone (1), 3,4,5,3′,5′-pentahydroxybenzophenone (3) and 3,5,3′,5′- tetrahydroxy-4-methoxybenzophenone (4), as well as a xanthone, 1,3,6-trihydroxy-5-methoxy-7-(3′-methyl-2′-oxo-but-3′-enyl) xanthone (9), were isolated from the twigs of Garcinia cantleyana var. cantleyana. Eight known compounds, 3,4,5,3′-tetrahydroxy benzophenone (2), 1,3,5-trihydroxyxanthone (5), 1,3,8-trihydroxyxanthone (6), 2,4,7-trihydroxyxanthone (7), 1,3,5,7-tetrahydroxyxanthone (8), quercetin, glutin-5-en-3β-ol and friedelin were also isolated. The structures of the compounds were elucidated by spectroscopic methods. The compounds were investigated for their ability to inhibit low-density lipoprotein (LDL) oxidation and platelet aggregation in human whole blood in vitro. Most of the compounds showed strong antioxidant activity with compound 8 showing the highest inhibition with an IC 50 value of 0.5 μM, comparable to that of probucol. Among the compounds tested, only compound 4 exhibited strong inhibitory activity against platelet aggregation induced by arachidonic acid (AA), adenosine diphosphate (ADP) and collagen. Compounds 3, 5 and 8 showed selective inhibitory activity on platelet aggregation induced by ADP.

Original languageEnglish
Pages (from-to)58-63
Number of pages6
JournalPhytochemistry
Volume80
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Benzophenones
Garcinia
Xanthones
benzophenone
xanthones
platelet aggregation
low density lipoprotein
Platelets
Platelet Aggregation
LDL Lipoproteins
Human Activities
adenosine diphosphate
xanthone
Agglomeration
oxidation
Oxidation
Adenosine Diphosphate
probucol
Probucol
Quercetin

Keywords

  • Antiplatelet aggregation
  • Benzophenones
  • Garcinia cantleyana var. cantleyana
  • Guttiferae
  • LDL antioxidant activity
  • Xanthones

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Horticulture

Cite this

Benzophenones and xanthones from Garcinia cantleyana var. cantleyana and their inhibitory activities on human low-density lipoprotein oxidation and platelet aggregation. / Jantan, Ibrahim; Saputri, Fadlina Chany.

In: Phytochemistry, Vol. 80, 08.2012, p. 58-63.

Research output: Contribution to journalArticle

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