Benzodiazepines and putative 5-HT1A agonists increase hypertonic saline consumption in rehydrating rats

Steven J. Cooper, Asmawati Desa

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Male rats were adapted to a 22 hr water-deprivation schedule, and to a 30 min test of hypertonic (1.8 or 2.7%) NaCl solution ingestion. A novel benzodiazepine, Ro23-0364, recently reported to have anxiolytic activity in rats and squirrel monkeys but to have limited potential to produce unwanted side effects, produced significant dose-related increases in hypertonic saline ingestion. Midazolam, a benzodiazepine full agonist, increased salt intake but the effect was offset at higher doses by the induction of sedation. Three putative 5-HT1A agonists, proposed as nonbenzodiazepine-related anxiolytics, were also tested: the highly selective 8-OH-DPAT, gepirone and ipsapirone (TVX Q 7821). In each case, occasions when hypertonic saline consumption was significantly increased were detected. At 300 μg/kg of 8-OH-DPAT and 10 mg/kg of gepirone, the appearance of a pronounced flattened body posture effectively interfered with drinking responses. It appears possible that a behavioural action shared by benzodiazepines and 5-HT1A agonists may be responsible for the increased hypertonic saline ingestion.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume28
Issue number2
DOIs
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

Serotonin 5-HT1 Receptor Agonists
Benzodiazepines
Rats
8-Hydroxy-2-(di-n-propylamino)tetralin
Eating
Anti-Anxiety Agents
Water Deprivation
Saimiri
Midazolam
Posture
Drinking
Appointments and Schedules
Salts
Water
gepirone
hydroxide ion
ipsapirone

Keywords

  • 5-HT receptor
  • 8-OH-DPAT
  • Benzodiazepines
  • Gepirone
  • Hypertonic saline
  • Ipsapirone (TVX Q 7821)
  • Midazolam
  • Rats
  • Ro23-0364
  • Water-deprivation

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Benzodiazepines and putative 5-HT1A agonists increase hypertonic saline consumption in rehydrating rats. / Cooper, Steven J.; Desa, Asmawati.

In: Pharmacology, Biochemistry and Behavior, Vol. 28, No. 2, 1987, p. 187-191.

Research output: Contribution to journalArticle

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