Basement membrane formation post implantation with bilayered fibrin-fibroblast/fibrinkeratinocytes skin equivalent during wound healing process

M. M. Norhayati, Mazlyzam Abdul Latif, R. Asmah, N. H. Fuzina, S. Aminuddin, Ruszymah Idrus, O. Fauziah

Research output: Contribution to journalArticle

Abstract

Basement membrane is a ubiquitous extracellular matrix protein which provides the structural foundation for secure attachment and polarity of the epidermal basal cell, as a barrier function, separate components between epidermis and dermis layer and also give a firm attachment for the cell through continuous system of structural elements. The basement membrane also acts as a medium of communication with any cell types and controls their phenotype and differentiation process during wound healing. Thus, the major gold on this study is to determine the wound healing capacity by evaluation of basement membrane formation with their extracellular matrix development during B FF/FK SE implanted onto n=6 athymic mice. All wound transplanted with B FF/FK SE showed positive phenomenon after transplantation period. Grossly, after 30 days implantation, the wound margin showed healthy skin zone without necrosis. B FF/FK SE also showed an established basement membrane development with intercellular junctional communications that includes hemidesmosome, lamina lucida, lamina densa and anchoring fibrils network. These findings thus suggest that, wound transplanted with B FF/FK SE may be a suitable alternative management to wound healing in acute situation of burns or diabetic patients.

Original languageEnglish
JournalMalaysian Journal of Microscopy
Volume5
Issue number1
Publication statusPublished - 2009

Fingerprint

fibrin
wound healing
fibroblasts
Fibroblasts
Fibrin
basements
Basement Membrane
Wound Healing
implantation
Skin
membranes
attachment
Wounds and Injuries
communication
Communications Media
Hemidesmosomes
transplantation
epidermis
phenotype
necrosis

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine
  • Instrumentation

Cite this

Basement membrane formation post implantation with bilayered fibrin-fibroblast/fibrinkeratinocytes skin equivalent during wound healing process. / Norhayati, M. M.; Abdul Latif, Mazlyzam; Asmah, R.; Fuzina, N. H.; Aminuddin, S.; Idrus, Ruszymah; Fauziah, O.

In: Malaysian Journal of Microscopy, Vol. 5, No. 1, 2009.

Research output: Contribution to journalArticle

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AU - Abdul Latif, Mazlyzam

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AU - Fuzina, N. H.

AU - Aminuddin, S.

AU - Idrus, Ruszymah

AU - Fauziah, O.

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