Bacterial cellulose/acrylic acid hydrogel synthesized via electron beam irradiation: Accelerated burn wound healing in an animal model

Najwa Mohamad, Mohd Cairul Iqbal Mohd Amin, Manisha Pandey, Naveed Ahmad, Nor Fadilah Rajab

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Natural polymer-based hydrogels are of interest to health care professionals as wound dressings owing to their ability to absorb exudates and provide hydration for healing. The aims of this study were to develop and characterize bacterial cellulose/acrylic acid (BC/AA) hydrogels synthesized by electron beam irradiation and investigate its wound healing potential in an animal model. The BC/AA hydrogels were characterized by SEM, tensile strength, water absorptivity, and water vapor transmission rate (WVTR). The cytotoxicity of the hydrogels was investigated in L929 cells. Skin irritation and wound healing properties were evaluated in Sprague-Dawley rats. BC/AA hydrogels had a macroporous network structure, high swelling ratio (4000-6000% at 24 h), and high WVTR (2175-2280 g/m2/day). The hydrogels were non-toxic in the cell viability assay. In vivo experiments indicated that hydrogels promoted faster wound-healing, enhanced epithelialization, and accelerated fibroblast proliferation compared to that in the control group. These results suggest that BC/AA hydrogels are promising materials for burn dressings.

Original languageEnglish
Pages (from-to)312-320
Number of pages9
JournalCarbohydrate Polymers
Volume114
DOIs
Publication statusPublished - 19 Dec 2014

Fingerprint

Hydrogels
Hydrogel
Cellulose
Acrylics
Electron beams
Animals
Irradiation
Acids
Steam
Water vapor
Natural polymers
acrylic acid
Fibroblasts
Cytotoxicity
Health care
Hydration
Swelling
Rats
Assays
Skin

Keywords

  • Acrylic acid
  • Bacterial cellulose
  • Burn wound
  • Wound healing

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Bacterial cellulose/acrylic acid hydrogel synthesized via electron beam irradiation : Accelerated burn wound healing in an animal model. / Mohamad, Najwa; Mohd Amin, Mohd Cairul Iqbal; Pandey, Manisha; Ahmad, Naveed; Rajab, Nor Fadilah.

In: Carbohydrate Polymers, Vol. 114, 19.12.2014, p. 312-320.

Research output: Contribution to journalArticle

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