Bacterial cellulose film coating as drug delivery system

Physicochemical, thermal and drug release properties

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

There has been an increasing interest in the use of natural materials as drug delivery vehicles due to their biodegradability, biocompatibility and ready availability. These properties make bacterial cellulose (BC), from nata de coco, a promising biopolymer for drug delivery applications. The aim of this study was to investigate the film-coating and drug release properties of this biopolymer. Physicochemical, morphological and thermal properties of BC films were studied. Model tablets were film coated with BC, using a spray coating technique, and in vitro drug release studies of these tablets were investigated. It was found that BC exhibited excellent ability to form soft, flexible and foldable films without the addition of any plasticizer. They were comparable to Aquacoat ECD (with plasticizer) in tensile strength, percentage elongation and elasticity modulus. Differential scanning calorimetry (DSC) BC showed a high T g value indicating thermally stability of films. These results suggest that BC can be used as novel aqueous film-coating agent with lower cost and better film forming properties than existing film-coating agents.

Original languageEnglish
Pages (from-to)561-568
Number of pages8
JournalSains Malaysiana
Volume41
Issue number5
Publication statusPublished - May 2012

Fingerprint

Drug Delivery Systems
Cellulose
Hot Temperature
Plasticizers
Biopolymers
Tablets
Cocos
Tensile Strength
Elastic Modulus
Differential Scanning Calorimetry
Pharmaceutical Preparations
Drug Liberation
Costs and Cost Analysis

Keywords

  • Bacterial cellulose
  • Drug delivery
  • DSC
  • Film-coating
  • Young's modulus

ASJC Scopus subject areas

  • General

Cite this

Bacterial cellulose film coating as drug delivery system : Physicochemical, thermal and drug release properties. / Mohd Amin, Mohd Cairul Iqbal; Abadi, Abadi Gumah; Ahmad, Naveed; Katas, Haliza; Jamal, Jamia Azdina.

In: Sains Malaysiana, Vol. 41, No. 5, 05.2012, p. 561-568.

Research output: Contribution to journalArticle

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