Autologous mononuclear cells from different sources are seen to improve wound healing in patients with haematological malignancies

Wan Fariza Wan Jamaludin, Farina Mohamad Yusoff, Nor Azimah Ismail, Mohd Razif Mohd Idris, Sivakumar Palaniappan, Christopher N.G.Kee Kiat, Noraimy Abdullah, Seery Zaliza Azura Zaider, S Fadilah S. Abdul Wahid

Research output: Contribution to journalArticle

Abstract

Introduction: Immunosuppressive state due to haematological malignancies and chemotherapy may cause disruption to wound healing despite optimum conventional treatment and standard wound dressing. Non-healing wounds are predisposed to infection whereas chemotherapy dose reductions or interruptions are associated with poor survival. Background: Mononuclear cells contain progenitor cells including haematopoietic and mesenchymal stem cells, endothelial progenitor cells and fibroblasts which facilitate wound healing through cytokines, growth factor secretions, cell-cell interactions and provision of extracellular matrix scaffolding. Clinical applications of autologous mononuclear cells therapy in wound healing in non-malignant patients with critical limb ischaemia have been reported with remarkable outcome. Methods: We report three patients with haematological malignancies undergoing chemotherapy, who received autologous mononuclear cells implantation to treat non-healing wound after optimum conventional wound care. The sources of mononuclear cells (MNC) were from bone marrow (BM), peripheral blood (PB) and mobilised PB cells (mPB-MNC) using granulocyte colony stimulating factor (G-CSF). The cells were directly implanted into wound and below epidermis. Wound sizes and adverse effects from implantation were assessed at regular intervals. Results: All patients achieved wound healing within three months following autologous mononuclear cells implantation. No implantation adverse effects were observed. Conclusions: Autologous mononuclear cells therapy is a feasible alternative to conventional wound care to promote complete healing in non-healing wounds compounded by morbid factors such as haematological malignancies, chemotherapy, diabetes mellitus (DM), infections and prolonged immobility.

Original languageEnglish
Pages (from-to)61-67
Number of pages7
JournalMalaysian Journal of Pathology
Volume40
Issue number1
Publication statusPublished - 1 Apr 2018

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Hematologic Neoplasms
Wound Healing
Wounds and Injuries
Drug Therapy
Cell- and Tissue-Based Therapy
Granulocyte Colony-Stimulating Factor
Bandages
Immunosuppressive Agents
Hematopoietic Stem Cells
Infection
Mesenchymal Stromal Cells
Epidermis
Cell Communication
Bone Marrow Cells
Extracellular Matrix
Blood Cells
Intercellular Signaling Peptides and Proteins
Diabetes Mellitus
Stem Cells
Ischemia

Keywords

  • Autologous
  • Cell therapy
  • Haematological malignancies
  • Mononuclear cells
  • Wound healing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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Autologous mononuclear cells from different sources are seen to improve wound healing in patients with haematological malignancies. / Wan Jamaludin, Wan Fariza; Mohamad Yusoff, Farina; Ismail, Nor Azimah; Mohd Idris, Mohd Razif; Palaniappan, Sivakumar; Kiat, Christopher N.G.Kee; Abdullah, Noraimy; Zaider, Seery Zaliza Azura; S. Abdul Wahid, S Fadilah.

In: Malaysian Journal of Pathology, Vol. 40, No. 1, 01.04.2018, p. 61-67.

Research output: Contribution to journalArticle

Wan Jamaludin, WF, Mohamad Yusoff, F, Ismail, NA, Mohd Idris, MR, Palaniappan, S, Kiat, CNGK, Abdullah, N, Zaider, SZA & S. Abdul Wahid, SF 2018, 'Autologous mononuclear cells from different sources are seen to improve wound healing in patients with haematological malignancies', Malaysian Journal of Pathology, vol. 40, no. 1, pp. 61-67.
Wan Jamaludin, Wan Fariza ; Mohamad Yusoff, Farina ; Ismail, Nor Azimah ; Mohd Idris, Mohd Razif ; Palaniappan, Sivakumar ; Kiat, Christopher N.G.Kee ; Abdullah, Noraimy ; Zaider, Seery Zaliza Azura ; S. Abdul Wahid, S Fadilah. / Autologous mononuclear cells from different sources are seen to improve wound healing in patients with haematological malignancies. In: Malaysian Journal of Pathology. 2018 ; Vol. 40, No. 1. pp. 61-67.
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AU - Kiat, Christopher N.G.Kee

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