Autoimmune polyglandular syndrome presenting with jaundice and thrombocytopenia

Norasyikin A. Wahab @ A. Rahman, Rozita Mohd, M. J. Mohd Johan, Z. Suehazlyn

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To report an uncommon presentation of a rare case of autoimmune polyglandular syndrome type IIIb in an elderly woman. Clinical Presentation and Intervention: A 62-year-old woman presented with anaemic symptoms and jaundice. Blood tests showed macrocytic anaemia due to vitamin B12 deficiency with Coombs negative haemolysis. A thyroid function test was consistent with hypothyroidism. Autoimmune antibody assays were positive for anti-parietal cell, anti-intrinsic factor and anti-thyroid peroxidase antibodies. A final diagnosis of autoimmune thyroiditis with pernicious anaemia, which constituted autoimmune polyglandular syndrome type IIIb, was made and the patient was treated with L-thyroxine, vitamin B12 injection and a blood transfusion. She was discharged uneventfully after a week of hospitalization. Conclusion: This case showed that the presence of one autoimmune endocrine disease should prompt clinicians to look for other coexisting autoimmune diseases which may be asymptomatic despite positive autoantibodies.

Original languageEnglish
Pages (from-to)387-389
Number of pages3
JournalMedical Principles and Practice
Volume23
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Jaundice
Thrombocytopenia
Autoimmune Diseases
Macrocytic Anemia
Vitamin B 12 Deficiency
Endocrine System Diseases
Thyroid Function Tests
Autoimmune Thyroiditis
Pernicious Anemia
Iodide Peroxidase
Intrinsic Factor
Antibodies
Hematologic Tests
Vitamin B 12
Hemolysis
Hypothyroidism
Thyroxine
Blood Transfusion
Autoantibodies
Hospitalization

Keywords

  • Autoimmune polyglandular syndrome
  • Autoimmune thyroiditis
  • Hypergastrinaemia
  • Pernicious anaemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Autoimmune polyglandular syndrome presenting with jaundice and thrombocytopenia. / A. Wahab @ A. Rahman, Norasyikin; Mohd, Rozita; Mohd Johan, M. J.; Suehazlyn, Z.

In: Medical Principles and Practice, Vol. 23, No. 4, 2014, p. 387-389.

Research output: Contribution to journalArticle

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