Augmentation index is a better marker for cardiovascular risk in young Malaysian males: A comparison of involvement of pulse wave velocity, augmentation index, and C-reactive protein

Amilia Aminuddin, Kalaivani Chell, Oteh Maskon, Zaiton Zakaria, Aminuddin A. Karim, Wan Z. Ngah, Nor Anita M Nordin

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Abstract

Objectives: To determine the association between carotid femoral pulse wave velocity (PWVCF) and augmentation index (AI) with future cardiovascular disease (CVD) risk, and to assess whether high sensitivity C-reactive protein (hs-CRP) is an important mediator towards these vascular changes, among young men. Methods: This cross-sectional study was conducted at Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia from July 2011 to December 2012. Two hundred and eleven young men were recruited. Te PWVCF and AI were measured using Vicorder. High sensitivity C-reactive protein was measured by using immunological methods. Te future CVD risk was assessed by Framingham risk score (FRS) and age adjusted FRS (A-FRS). Data for analysis was conducted using the Statistical Package of Social Sciences Version 15 (SPSS Inc., Chicago, IL, USA). Results: Te mean age of the subjects was 27.09 (95% confidence intervals [CI] 26.39-27.79) years old. Those with ≥2 risk factors had significantly higher AI [10.09 (95% CI: 9.06-11.12) versus 6.56 (95% CI: 5.54-7.57) (p=0.001), but not PWVCF 7.45 (95% CI: 7.29-7.61) m/s versus 7.29 (95% CI: 7.06-7.51) m/s, (p=0.90) when compared to the healthy subjects. High sensitivity C-reactive protein was not an independent determinant for PWVCF and AI. Only AI was significantly associated with FRS and A-FRS (p=0.0001). Conclusions: To assess the impact of risk factors on vascular damage and for future assessment of CVD risk among the young men, AI may be a better marker than PWVCF. The increase in AI among these subjects was not related to hs-CRP.

Original languageEnglish
Pages (from-to)138-146
Number of pages9
JournalSaudi Medical Journal
Volume35
Issue number2
Publication statusPublished - 2014

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Pulse Wave Analysis
C-Reactive Protein
Confidence Intervals
Cardiovascular Diseases
Malaysia
Blood Vessels
Social Sciences
Thigh
Healthy Volunteers
Cross-Sectional Studies

ASJC Scopus subject areas

  • Medicine(all)

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Augmentation index is a better marker for cardiovascular risk in young Malaysian males : A comparison of involvement of pulse wave velocity, augmentation index, and C-reactive protein. / Aminuddin, Amilia; Chell, Kalaivani; Maskon, Oteh; Zakaria, Zaiton; Karim, Aminuddin A.; Ngah, Wan Z.; Nordin, Nor Anita M.

In: Saudi Medical Journal, Vol. 35, No. 2, 2014, p. 138-146.

Research output: Contribution to journalArticle

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title = "Augmentation index is a better marker for cardiovascular risk in young Malaysian males: A comparison of involvement of pulse wave velocity, augmentation index, and C-reactive protein",
abstract = "Objectives: To determine the association between carotid femoral pulse wave velocity (PWVCF) and augmentation index (AI) with future cardiovascular disease (CVD) risk, and to assess whether high sensitivity C-reactive protein (hs-CRP) is an important mediator towards these vascular changes, among young men. Methods: This cross-sectional study was conducted at Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia from July 2011 to December 2012. Two hundred and eleven young men were recruited. Te PWVCF and AI were measured using Vicorder. High sensitivity C-reactive protein was measured by using immunological methods. Te future CVD risk was assessed by Framingham risk score (FRS) and age adjusted FRS (A-FRS). Data for analysis was conducted using the Statistical Package of Social Sciences Version 15 (SPSS Inc., Chicago, IL, USA). Results: Te mean age of the subjects was 27.09 (95{\%} confidence intervals [CI] 26.39-27.79) years old. Those with ≥2 risk factors had significantly higher AI [10.09 (95{\%} CI: 9.06-11.12) versus 6.56 (95{\%} CI: 5.54-7.57) (p=0.001), but not PWVCF 7.45 (95{\%} CI: 7.29-7.61) m/s versus 7.29 (95{\%} CI: 7.06-7.51) m/s, (p=0.90) when compared to the healthy subjects. High sensitivity C-reactive protein was not an independent determinant for PWVCF and AI. Only AI was significantly associated with FRS and A-FRS (p=0.0001). Conclusions: To assess the impact of risk factors on vascular damage and for future assessment of CVD risk among the young men, AI may be a better marker than PWVCF. The increase in AI among these subjects was not related to hs-CRP.",
author = "Amilia Aminuddin and Kalaivani Chell and Oteh Maskon and Zaiton Zakaria and Karim, {Aminuddin A.} and Ngah, {Wan Z.} and Nordin, {Nor Anita M}",
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AU - Aminuddin, Amilia

AU - Chell, Kalaivani

AU - Maskon, Oteh

AU - Zakaria, Zaiton

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AU - Ngah, Wan Z.

AU - Nordin, Nor Anita M

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N2 - Objectives: To determine the association between carotid femoral pulse wave velocity (PWVCF) and augmentation index (AI) with future cardiovascular disease (CVD) risk, and to assess whether high sensitivity C-reactive protein (hs-CRP) is an important mediator towards these vascular changes, among young men. Methods: This cross-sectional study was conducted at Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia from July 2011 to December 2012. Two hundred and eleven young men were recruited. Te PWVCF and AI were measured using Vicorder. High sensitivity C-reactive protein was measured by using immunological methods. Te future CVD risk was assessed by Framingham risk score (FRS) and age adjusted FRS (A-FRS). Data for analysis was conducted using the Statistical Package of Social Sciences Version 15 (SPSS Inc., Chicago, IL, USA). Results: Te mean age of the subjects was 27.09 (95% confidence intervals [CI] 26.39-27.79) years old. Those with ≥2 risk factors had significantly higher AI [10.09 (95% CI: 9.06-11.12) versus 6.56 (95% CI: 5.54-7.57) (p=0.001), but not PWVCF 7.45 (95% CI: 7.29-7.61) m/s versus 7.29 (95% CI: 7.06-7.51) m/s, (p=0.90) when compared to the healthy subjects. High sensitivity C-reactive protein was not an independent determinant for PWVCF and AI. Only AI was significantly associated with FRS and A-FRS (p=0.0001). Conclusions: To assess the impact of risk factors on vascular damage and for future assessment of CVD risk among the young men, AI may be a better marker than PWVCF. The increase in AI among these subjects was not related to hs-CRP.

AB - Objectives: To determine the association between carotid femoral pulse wave velocity (PWVCF) and augmentation index (AI) with future cardiovascular disease (CVD) risk, and to assess whether high sensitivity C-reactive protein (hs-CRP) is an important mediator towards these vascular changes, among young men. Methods: This cross-sectional study was conducted at Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia from July 2011 to December 2012. Two hundred and eleven young men were recruited. Te PWVCF and AI were measured using Vicorder. High sensitivity C-reactive protein was measured by using immunological methods. Te future CVD risk was assessed by Framingham risk score (FRS) and age adjusted FRS (A-FRS). Data for analysis was conducted using the Statistical Package of Social Sciences Version 15 (SPSS Inc., Chicago, IL, USA). Results: Te mean age of the subjects was 27.09 (95% confidence intervals [CI] 26.39-27.79) years old. Those with ≥2 risk factors had significantly higher AI [10.09 (95% CI: 9.06-11.12) versus 6.56 (95% CI: 5.54-7.57) (p=0.001), but not PWVCF 7.45 (95% CI: 7.29-7.61) m/s versus 7.29 (95% CI: 7.06-7.51) m/s, (p=0.90) when compared to the healthy subjects. High sensitivity C-reactive protein was not an independent determinant for PWVCF and AI. Only AI was significantly associated with FRS and A-FRS (p=0.0001). Conclusions: To assess the impact of risk factors on vascular damage and for future assessment of CVD risk among the young men, AI may be a better marker than PWVCF. The increase in AI among these subjects was not related to hs-CRP.

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