Association of HLA locus variant in parkinson's disease

Y. Zhao, A. A. Gopalai, A. Ahmad-Annuar, E. W L Teng, K. M. Prakash, L. C S Tan, W. L. Au, H. H. Li, S. Y. Lim, S. K. Lim, Y. B. Chong, L. P. Tan, Norlinah Mohamed Ibrahim, E. K. Tan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR)=0.77, 95% confidence interval (CI)=0.62, 0.96, p=0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD.

Original languageEnglish
Pages (from-to)501-504
Number of pages4
JournalClinical Genetics
Volume84
Issue number5
DOIs
Publication statusPublished - Nov 2013

Fingerprint

HLA Antigens
Parkinson Disease
Genome-Wide Association Study
Logistic Models
Alleles
Odds Ratio
Regression Analysis
Confidence Intervals
Population
Genes

Keywords

  • Chinese
  • Gene
  • Parkinson's disease
  • Polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Zhao, Y., Gopalai, A. A., Ahmad-Annuar, A., Teng, E. W. L., Prakash, K. M., Tan, L. C. S., ... Tan, E. K. (2013). Association of HLA locus variant in parkinson's disease. Clinical Genetics, 84(5), 501-504. https://doi.org/10.1111/cge.12024

Association of HLA locus variant in parkinson's disease. / Zhao, Y.; Gopalai, A. A.; Ahmad-Annuar, A.; Teng, E. W L; Prakash, K. M.; Tan, L. C S; Au, W. L.; Li, H. H.; Lim, S. Y.; Lim, S. K.; Chong, Y. B.; Tan, L. P.; Mohamed Ibrahim, Norlinah; Tan, E. K.

In: Clinical Genetics, Vol. 84, No. 5, 11.2013, p. 501-504.

Research output: Contribution to journalArticle

Zhao, Y, Gopalai, AA, Ahmad-Annuar, A, Teng, EWL, Prakash, KM, Tan, LCS, Au, WL, Li, HH, Lim, SY, Lim, SK, Chong, YB, Tan, LP, Mohamed Ibrahim, N & Tan, EK 2013, 'Association of HLA locus variant in parkinson's disease', Clinical Genetics, vol. 84, no. 5, pp. 501-504. https://doi.org/10.1111/cge.12024
Zhao Y, Gopalai AA, Ahmad-Annuar A, Teng EWL, Prakash KM, Tan LCS et al. Association of HLA locus variant in parkinson's disease. Clinical Genetics. 2013 Nov;84(5):501-504. https://doi.org/10.1111/cge.12024
Zhao, Y. ; Gopalai, A. A. ; Ahmad-Annuar, A. ; Teng, E. W L ; Prakash, K. M. ; Tan, L. C S ; Au, W. L. ; Li, H. H. ; Lim, S. Y. ; Lim, S. K. ; Chong, Y. B. ; Tan, L. P. ; Mohamed Ibrahim, Norlinah ; Tan, E. K. / Association of HLA locus variant in parkinson's disease. In: Clinical Genetics. 2013 ; Vol. 84, No. 5. pp. 501-504.
@article{a5c54379df4d45ce8a0fcebac2d211bf,
title = "Association of HLA locus variant in parkinson's disease",
abstract = "A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR)=0.77, 95{\%} confidence interval (CI)=0.62, 0.96, p=0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD.",
keywords = "Chinese, Gene, Parkinson's disease, Polymorphism",
author = "Y. Zhao and Gopalai, {A. A.} and A. Ahmad-Annuar and Teng, {E. W L} and Prakash, {K. M.} and Tan, {L. C S} and Au, {W. L.} and Li, {H. H.} and Lim, {S. Y.} and Lim, {S. K.} and Chong, {Y. B.} and Tan, {L. P.} and {Mohamed Ibrahim}, Norlinah and Tan, {E. K.}",
year = "2013",
month = "11",
doi = "10.1111/cge.12024",
language = "English",
volume = "84",
pages = "501--504",
journal = "Clinical Genetics",
issn = "0009-9163",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Association of HLA locus variant in parkinson's disease

AU - Zhao, Y.

AU - Gopalai, A. A.

AU - Ahmad-Annuar, A.

AU - Teng, E. W L

AU - Prakash, K. M.

AU - Tan, L. C S

AU - Au, W. L.

AU - Li, H. H.

AU - Lim, S. Y.

AU - Lim, S. K.

AU - Chong, Y. B.

AU - Tan, L. P.

AU - Mohamed Ibrahim, Norlinah

AU - Tan, E. K.

PY - 2013/11

Y1 - 2013/11

N2 - A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR)=0.77, 95% confidence interval (CI)=0.62, 0.96, p=0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD.

AB - A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR)=0.77, 95% confidence interval (CI)=0.62, 0.96, p=0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD.

KW - Chinese

KW - Gene

KW - Parkinson's disease

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=84885869304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885869304&partnerID=8YFLogxK

U2 - 10.1111/cge.12024

DO - 10.1111/cge.12024

M3 - Article

C2 - 23083294

AN - SCOPUS:84885869304

VL - 84

SP - 501

EP - 504

JO - Clinical Genetics

JF - Clinical Genetics

SN - 0009-9163

IS - 5

ER -