Association of hippocampal sclerosis with cortical dysgenesis in patients with epilepsy

Raymond Azman Ali, D. R. Fish, J. M. Stevens, M. J. Cook, S. M. Sisodiya, S. D. Shorvon

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

The possible dual occurrence of hippocampal sclerosis (HS) and other structural lesions (especially cortical dysgenesis [CD]) is well established in patients with chronic partial epilepsy. We describe the frequency of additional CD in a series of 100 patients with evidence of HS, using volumetric MRI. Additional, often subtle, CD was present in 15 patients: subependymal heterotopia (six), forme fruste of tuberous sclerosis (two), focal macrogyria (two), focal cortical dysplasia (one), laminar heterotopia (one), bilateral schizencephaly (one), and simplified gyral patterns (two). In contrast, in 46 healthy volunteers, only one had possible CD (p < 0.05). Only 2 of 15 patients had a history of childhood febrile convulsions. HS is a heterogeneous condition; patients being evaluated for temporal lobe surgery should be carefully screened for additional CD using appropriate MR techniques.

Original languageEnglish
Pages (from-to)1841-1845
Number of pages5
JournalNeurology
Volume44
Issue number10
Publication statusPublished - Oct 1994
Externally publishedYes

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Sclerosis
Epilepsy
Lissencephaly
Malformations of Cortical Development
Febrile Seizures
Tuberous Sclerosis
Partial Epilepsy
Temporal Lobe
Healthy Volunteers

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ali, R. A., Fish, D. R., Stevens, J. M., Cook, M. J., Sisodiya, S. M., & Shorvon, S. D. (1994). Association of hippocampal sclerosis with cortical dysgenesis in patients with epilepsy. Neurology, 44(10), 1841-1845.

Association of hippocampal sclerosis with cortical dysgenesis in patients with epilepsy. / Ali, Raymond Azman; Fish, D. R.; Stevens, J. M.; Cook, M. J.; Sisodiya, S. M.; Shorvon, S. D.

In: Neurology, Vol. 44, No. 10, 10.1994, p. 1841-1845.

Research output: Contribution to journalArticle

Ali, RA, Fish, DR, Stevens, JM, Cook, MJ, Sisodiya, SM & Shorvon, SD 1994, 'Association of hippocampal sclerosis with cortical dysgenesis in patients with epilepsy', Neurology, vol. 44, no. 10, pp. 1841-1845.
Ali RA, Fish DR, Stevens JM, Cook MJ, Sisodiya SM, Shorvon SD. Association of hippocampal sclerosis with cortical dysgenesis in patients with epilepsy. Neurology. 1994 Oct;44(10):1841-1845.
Ali, Raymond Azman ; Fish, D. R. ; Stevens, J. M. ; Cook, M. J. ; Sisodiya, S. M. ; Shorvon, S. D. / Association of hippocampal sclerosis with cortical dysgenesis in patients with epilepsy. In: Neurology. 1994 ; Vol. 44, No. 10. pp. 1841-1845.
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