Association of hepatocyte nuclear factor 4 alpha polymorphisms with type 2 diabetes with or without metabolic syndrome in Malaysia

Riyadh Saif-Ali, Roslan Harun, Nor Azmi Kamaruddin, Saad Al-Jassabi, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study investigated the association of hepatocyte nuclear factor 4 (HNF4) alpha single nucleotide polymorphisms (SNPs) with type 2 diabetes with or without metabolic syndrome in Malaysia. Nine HNF4 alpha SNPs were genotyped in 390 type 2 diabetic subjects with metabolic syndrome, 135 type 2 diabetic subjects without metabolic syndrome, and 160 control subjects. The SNPs rs4810424, rs1884613, and rs2144908 were associated with protection against type 2 diabetes without metabolic syndrome (recessive P = 0.018, OR 0.32; P = 0.004, OR 0.25; P = 0.005, OR 0.24, respectively). The 6-SNP haplotype2 CCCGTC.

Original languageEnglish
Pages (from-to)298-308
Number of pages11
JournalBiochemical Genetics
Volume50
Issue number3-4
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Hepatocyte Nuclear Factor 4
diabetes
Malaysia
metabolic syndrome
Medical problems
Polymorphism
noninsulin-dependent diabetes mellitus
polymorphism
Type 2 Diabetes Mellitus
single nucleotide polymorphism
hepatocytes
Single Nucleotide Polymorphism
Nucleotides

Keywords

  • Haplotype
  • Hepatocyte nuclear factor 4 alpha
  • Metabolic syndrome
  • Single nucleotide polymorphisms
  • Type 2 diabetes

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Association of hepatocyte nuclear factor 4 alpha polymorphisms with type 2 diabetes with or without metabolic syndrome in Malaysia. / Saif-Ali, Riyadh; Harun, Roslan; Kamaruddin, Nor Azmi; Al-Jassabi, Saad; Ngah, Wan Zurinah Wan.

In: Biochemical Genetics, Vol. 50, No. 3-4, 04.2012, p. 298-308.

Research output: Contribution to journalArticle

Saif-Ali, Riyadh ; Harun, Roslan ; Kamaruddin, Nor Azmi ; Al-Jassabi, Saad ; Ngah, Wan Zurinah Wan. / Association of hepatocyte nuclear factor 4 alpha polymorphisms with type 2 diabetes with or without metabolic syndrome in Malaysia. In: Biochemical Genetics. 2012 ; Vol. 50, No. 3-4. pp. 298-308.
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