Association of epithelial sodium channel with blood pressure

A systematic review

Noor Akmal Shareela Ismail, Nur F. Abdul Sani, Jemaima Che Hamzah, Azlan M. Hamzah, Siti N. Hamid

Research output: Contribution to journalArticle

Abstract

To determine the role of epithelial sodium channel (ENaC) in increasing blood pressure. MEDLINE data base from January 1922 to July 2013 were systematically searched using a sensitive search strategy. Observational and clinical human studies were included in the review. Two reviewers independently evaluated studies for inclusion and extracted the data using a standardized data collection form. Eight studies were identified from the search. Certain population were involved, Chinese, Australian, Finland and certain parts of United State of America. Gene mutations in ENaC subunits are suggested to elevate blood pressure. Several molecular variants of ENaC subunits have been identified to suggest the association of ENaC with the prevalence of hypertension in certain population. However, these variants did not clearly demonstrate the link to the increased level of blood pressure. Few mechanistic pathways associated with ENaC expression need to be further elucidated through in vivo experiments.

Original languageEnglish
Pages (from-to)426-433
Number of pages8
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume5
Issue number6
Publication statusPublished - 2014

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Epithelial Sodium Channels
Blood pressure
Blood Pressure
Finland
MEDLINE
Population
Genes
Databases
Hypertension
Mutation
Experiments

Keywords

  • Blood pressure
  • Epithelium sodium channel
  • Hypertension

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Association of epithelial sodium channel with blood pressure : A systematic review. / Ismail, Noor Akmal Shareela; Abdul Sani, Nur F.; Che Hamzah, Jemaima; Hamzah, Azlan M.; Hamid, Siti N.

In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 5, No. 6, 2014, p. 426-433.

Research output: Contribution to journalArticle

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