Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder

Nur Elia Nazree, Zahurin Mohamed, Gavin P. Reynolds, Shamsul Mohd Zain, Ruziana Masiran, Hatta Sidi, Lu Ann Chong, Anne Yee Hway, Aida Syarinaz Adlan, Nor Zuraida Zainal

Research output: Contribution to journalArticle

Abstract

Introduction: The occurrence of female sexual dysfunction (FSD) in patients with major depressive disorder (MDD) receiving selective serotonin reuptake inhibitors (SSRIs) treatment gives negative impacts on patients' quality of life and causes treatment discontinuation. We aimed to investigate whether genetic polymorphism of identified candidate gene is associated with FSD in our study population. Methods: This is a cross-sectional study. A total of 95 female patients with MDD who met the criteria of the study were recruited and were specifically assessed on the sexual function by trained psychiatrists. Patients' DNA was genotyped for BDNF Val66Met polymorphism using real-time polymerase chain reaction. Results: The prevalence of FSD in this study is 31.6%. In the FSD group, patients with problematic marriage were significantly more frequent compared with patients who did not have problematic marriage (P=0.009). Significant association was detected in the lubrication domain with BDNF Val66Met polymorphism (P=0.030) using additive genetic model, with even stronger association when using the recessive model (P=0.013). Discussion: This study suggested that there was no significant association between BDNF Val66Met with FSD. However, this polymorphism is significantly associated with lubrication disorder in patients treated with SSRIs.

Original languageEnglish
JournalAsia-Pacific Psychiatry
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

Brain-Derived Neurotrophic Factor
Major Depressive Disorder
Serotonin Uptake Inhibitors
Valine
Methionine
Lubrication
Marriage
Therapeutics
Genetic Models
Genetic Polymorphisms
Psychiatry
Real-Time Polymerase Chain Reaction
Cross-Sectional Studies
Quality of Life
DNA
Population
Genes

Keywords

  • Brain-derived neurotrophic factor
  • Female sexual dysfunction
  • Major depressive disorder
  • Pharmacogenetics
  • Selective serotonin reuptake inhibitor

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder. / Nazree, Nur Elia; Mohamed, Zahurin; Reynolds, Gavin P.; Mohd Zain, Shamsul; Masiran, Ruziana; Sidi, Hatta; Chong, Lu Ann; Hway, Anne Yee; Adlan, Aida Syarinaz; Zainal, Nor Zuraida.

In: Asia-Pacific Psychiatry, 2015.

Research output: Contribution to journalArticle

Nazree, Nur Elia ; Mohamed, Zahurin ; Reynolds, Gavin P. ; Mohd Zain, Shamsul ; Masiran, Ruziana ; Sidi, Hatta ; Chong, Lu Ann ; Hway, Anne Yee ; Adlan, Aida Syarinaz ; Zainal, Nor Zuraida. / Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder. In: Asia-Pacific Psychiatry. 2015.
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abstract = "Introduction: The occurrence of female sexual dysfunction (FSD) in patients with major depressive disorder (MDD) receiving selective serotonin reuptake inhibitors (SSRIs) treatment gives negative impacts on patients' quality of life and causes treatment discontinuation. We aimed to investigate whether genetic polymorphism of identified candidate gene is associated with FSD in our study population. Methods: This is a cross-sectional study. A total of 95 female patients with MDD who met the criteria of the study were recruited and were specifically assessed on the sexual function by trained psychiatrists. Patients' DNA was genotyped for BDNF Val66Met polymorphism using real-time polymerase chain reaction. Results: The prevalence of FSD in this study is 31.6{\%}. In the FSD group, patients with problematic marriage were significantly more frequent compared with patients who did not have problematic marriage (P=0.009). Significant association was detected in the lubrication domain with BDNF Val66Met polymorphism (P=0.030) using additive genetic model, with even stronger association when using the recessive model (P=0.013). Discussion: This study suggested that there was no significant association between BDNF Val66Met with FSD. However, this polymorphism is significantly associated with lubrication disorder in patients treated with SSRIs.",
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AU - Nazree, Nur Elia

AU - Mohamed, Zahurin

AU - Reynolds, Gavin P.

AU - Mohd Zain, Shamsul

AU - Masiran, Ruziana

AU - Sidi, Hatta

AU - Chong, Lu Ann

AU - Hway, Anne Yee

AU - Adlan, Aida Syarinaz

AU - Zainal, Nor Zuraida

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