Association of BDNF Polymorphisms with the Risk of Epilepsy

a Multicenter Study

Hidayati Mohd Sha’ari, Batoul Sadat Haerian, Larry Baum, Hui Jan Tan, Mohd Hanip Rafia, Patrick Kwan, Stacey S. Cherny, Pak Chung Sham, Hongsheng Gui, Raymond Azman Ali, Kheng Seang Lim, Zahurin Mohamed

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Epilepsy is a common neurological disease characterized by recurrent unprovoked seizures. Evidence suggested that abnormal activity of brain-derived neurotrophic factor (BDNF) contributes to the pathogenesis of epilepsy. Some previous studies identified association between genetic variants of BDNF and risk of epilepsy. In this study, this association has been examined in the Hong Kong and Malaysian epilepsy cohorts. Genomic DNA of 6047 subjects (1640 patients with epilepsy and 4407 healthy individuals) was genotyped for rs6265, rs11030104, rs7103411, and rs7127507 polymorphisms by using Sequenom MassArray and Illumina HumanHap 610-Quad or 550-Duo BeadChip arrays techniques. Results showed significant association between rs6265 T, rs7103411 C, and rs7127507 T and cryptgenic epilepsy risk (p = 0.00003, p = 0.0002, and p = 0.002, respectively) or between rs6265 and rs7103411 and symptomatic epilepsy risk in Malaysian Indians (TT vs. CC, p = 0.004 and T vs. C, p = 0.0002, respectively) as well as between rs6265 T and risk of cryptogenic epilepsy in Malaysian Chinese (p = 0.005). The T<inf>rs6265</inf>-C<inf>rs7103411</inf>-T<inf>rs7127507</inf> was significantly associated with cryptogenic epilepsy in Malaysian Indians (p = 0.00005). In conclusion, our results suggest that BDNF polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese.

Original languageEnglish
JournalMolecular Neurobiology
DOIs
Publication statusAccepted/In press - 16 Apr 2015

Fingerprint

Brain-Derived Neurotrophic Factor
Multicenter Studies
Epilepsy
Hong Kong
Seizures
DNA

Keywords

  • BDNF
  • Epilepsy
  • Polymorphism
  • Susceptibility

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Sha’ari, H. M., Haerian, B. S., Baum, L., Tan, H. J., Rafia, M. H., Kwan, P., ... Mohamed, Z. (Accepted/In press). Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study. Molecular Neurobiology. https://doi.org/10.1007/s12035-015-9150-1

Association of BDNF Polymorphisms with the Risk of Epilepsy : a Multicenter Study. / Sha’ari, Hidayati Mohd; Haerian, Batoul Sadat; Baum, Larry; Tan, Hui Jan; Rafia, Mohd Hanip; Kwan, Patrick; Cherny, Stacey S.; Sham, Pak Chung; Gui, Hongsheng; Ali, Raymond Azman; Lim, Kheng Seang; Mohamed, Zahurin.

In: Molecular Neurobiology, 16.04.2015.

Research output: Contribution to journalArticle

Sha’ari, HM, Haerian, BS, Baum, L, Tan, HJ, Rafia, MH, Kwan, P, Cherny, SS, Sham, PC, Gui, H, Ali, RA, Lim, KS & Mohamed, Z 2015, 'Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study', Molecular Neurobiology. https://doi.org/10.1007/s12035-015-9150-1
Sha’ari, Hidayati Mohd ; Haerian, Batoul Sadat ; Baum, Larry ; Tan, Hui Jan ; Rafia, Mohd Hanip ; Kwan, Patrick ; Cherny, Stacey S. ; Sham, Pak Chung ; Gui, Hongsheng ; Ali, Raymond Azman ; Lim, Kheng Seang ; Mohamed, Zahurin. / Association of BDNF Polymorphisms with the Risk of Epilepsy : a Multicenter Study. In: Molecular Neurobiology. 2015.
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