Association between trace element and heavy metal levels in hair and nail with prostate cancer

Golgis Karimi, Suzana Shahar, Nasim Homayouni, Roslee Rajikan, Nor Faizah Abu Bakar, Mohd. Sham Othman

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

While associations between trace elements and heavy metals with prostate cancer are still debatable, they have been considered as risk factors for prostate cancer. Thus, this study aimed to detect any links between selected minerals and heavy metals including Se, Zn, Cu, Mn and Fe with prostate cancer. A case control study was carried out among 100 subjects (case n=50, control n=50), matched for age and ethnicity. Trace elements and heavy metals level in hair and nail samples were determined by ICP-MS. Mean selenium levels in hair and nail of the cases were significantly lower as compared to controls. A similar trend was noted for zinc in both hair and nail samples, whereas the mean level of copper was significantly higher in cases than controls. Similar elevation was noted for iron and manganese (p<0.05 for all parameters). Low levels of selenium and zinc and high levels of copper, iron and manganese appear to be associated with the risk of prostate cancer. Further studies to elucidate the causal mechanisms and appropriate chemopreventive measures are needed.

Original languageEnglish
Pages (from-to)4249-4253
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume13
Issue number9
DOIs
Publication statusPublished - 2012

Fingerprint

Trace Elements
Nails
Heavy Metals
Hair
Prostatic Neoplasms
Manganese
Selenium
Zinc
Copper
Iron
Minerals
Case-Control Studies

Keywords

  • Case
  • Control study
  • Hair and nail samples
  • Heavy metals
  • Prostate cancer
  • Trace elements

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Association between trace element and heavy metal levels in hair and nail with prostate cancer. / Karimi, Golgis; Shahar, Suzana; Homayouni, Nasim; Rajikan, Roslee; Bakar, Nor Faizah Abu; Othman, Mohd. Sham.

In: Asian Pacific Journal of Cancer Prevention, Vol. 13, No. 9, 2012, p. 4249-4253.

Research output: Contribution to journalArticle

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