Association between isoflavones consumption and cognitive function and comorbidities among older adults residing in the State of Johor, Malaysia

A. H. Bibi Nabihah, Suzana Shahar, Hasnah Haron

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: This two-phase longitudinal study sought to determine the association between isoflavones intake on cognitive function and comorbidities among older adults from the state of Johor, Malaysia. Methods: Phase I involved baseline data collection to examine the association between isoflavones intake and cognitive function among 400 respondents aged 60-years and above, recruited through multistage random sampling. Phase 2 determined the association between isoflavones intake at the baseline and comorbidities at an 18-month follow-up. The baseline data collected included information on socio-demographics, health status, andunpometric measurements, and dietary intake using a dietary history questionnaire (DHQ). Each participant's cognitive function was evaluated using a mini mental state examination (MMSE), digit span, digit symbol, and geriatric depression scale (GDS). Results: The daily intake of total isoflavones, daidzein, and genistein were 19.1 ±19.7,11.7 ±12.3 and 7.6+8.1 mg/day, respectively. There was no significant association between isoflavones intake, and specific cognitive function including global, memory, executive functions, and depression. However, there was a significant association (p < 0.05) between isoflavones intake r=0.131 (95% CI: 0.064-0.199), daidzein intake r0.132 (95% CI: 0.064-0.199), and genistein intake ra0.129 (95% CI: 0.062-0.197) with memory (digit span) after adjustment for age, gender, educational level, and body mass index (11M1). No association was found between isoflavones intake and comorbidities (p > 0.05). Conclusion: This study found an association between isoflavones intake and memory function, but not with global cognitive, executive functions, depression, and comorbidities. There is a need to promote adequate isoflavones intake in view of its association with memory function.

Original languageEnglish
Pages (from-to)29-39
Number of pages11
JournalMalaysian Journal of Nutrition
Volume22
Issue number1
Publication statusPublished - 2016

Fingerprint

Isoflavones
Malaysia
isoflavones
cognition
Cognition
Comorbidity
Executive Function
Depression
diet history
daidzein
Genistein
genistein
longitudinal studies
comorbidity
health status
Geriatrics
Health Status
Longitudinal Studies
food intake
demographic statistics

Keywords

  • Cognitive function
  • Comorbidities
  • Isoflavones
  • Older adults
  • Phytoestrogen

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

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title = "Association between isoflavones consumption and cognitive function and comorbidities among older adults residing in the State of Johor, Malaysia",
abstract = "Introduction: This two-phase longitudinal study sought to determine the association between isoflavones intake on cognitive function and comorbidities among older adults from the state of Johor, Malaysia. Methods: Phase I involved baseline data collection to examine the association between isoflavones intake and cognitive function among 400 respondents aged 60-years and above, recruited through multistage random sampling. Phase 2 determined the association between isoflavones intake at the baseline and comorbidities at an 18-month follow-up. The baseline data collected included information on socio-demographics, health status, andunpometric measurements, and dietary intake using a dietary history questionnaire (DHQ). Each participant's cognitive function was evaluated using a mini mental state examination (MMSE), digit span, digit symbol, and geriatric depression scale (GDS). Results: The daily intake of total isoflavones, daidzein, and genistein were 19.1 ±19.7,11.7 ±12.3 and 7.6+8.1 mg/day, respectively. There was no significant association between isoflavones intake, and specific cognitive function including global, memory, executive functions, and depression. However, there was a significant association (p < 0.05) between isoflavones intake r=0.131 (95{\%} CI: 0.064-0.199), daidzein intake r0.132 (95{\%} CI: 0.064-0.199), and genistein intake ra0.129 (95{\%} CI: 0.062-0.197) with memory (digit span) after adjustment for age, gender, educational level, and body mass index (11M1). No association was found between isoflavones intake and comorbidities (p > 0.05). Conclusion: This study found an association between isoflavones intake and memory function, but not with global cognitive, executive functions, depression, and comorbidities. There is a need to promote adequate isoflavones intake in view of its association with memory function.",
keywords = "Cognitive function, Comorbidities, Isoflavones, Older adults, Phytoestrogen",
author = "{Bibi Nabihah}, {A. H.} and Suzana Shahar and Hasnah Haron",
year = "2016",
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TY - JOUR

T1 - Association between isoflavones consumption and cognitive function and comorbidities among older adults residing in the State of Johor, Malaysia

AU - Bibi Nabihah, A. H.

AU - Shahar, Suzana

AU - Haron, Hasnah

PY - 2016

Y1 - 2016

N2 - Introduction: This two-phase longitudinal study sought to determine the association between isoflavones intake on cognitive function and comorbidities among older adults from the state of Johor, Malaysia. Methods: Phase I involved baseline data collection to examine the association between isoflavones intake and cognitive function among 400 respondents aged 60-years and above, recruited through multistage random sampling. Phase 2 determined the association between isoflavones intake at the baseline and comorbidities at an 18-month follow-up. The baseline data collected included information on socio-demographics, health status, andunpometric measurements, and dietary intake using a dietary history questionnaire (DHQ). Each participant's cognitive function was evaluated using a mini mental state examination (MMSE), digit span, digit symbol, and geriatric depression scale (GDS). Results: The daily intake of total isoflavones, daidzein, and genistein were 19.1 ±19.7,11.7 ±12.3 and 7.6+8.1 mg/day, respectively. There was no significant association between isoflavones intake, and specific cognitive function including global, memory, executive functions, and depression. However, there was a significant association (p < 0.05) between isoflavones intake r=0.131 (95% CI: 0.064-0.199), daidzein intake r0.132 (95% CI: 0.064-0.199), and genistein intake ra0.129 (95% CI: 0.062-0.197) with memory (digit span) after adjustment for age, gender, educational level, and body mass index (11M1). No association was found between isoflavones intake and comorbidities (p > 0.05). Conclusion: This study found an association between isoflavones intake and memory function, but not with global cognitive, executive functions, depression, and comorbidities. There is a need to promote adequate isoflavones intake in view of its association with memory function.

AB - Introduction: This two-phase longitudinal study sought to determine the association between isoflavones intake on cognitive function and comorbidities among older adults from the state of Johor, Malaysia. Methods: Phase I involved baseline data collection to examine the association between isoflavones intake and cognitive function among 400 respondents aged 60-years and above, recruited through multistage random sampling. Phase 2 determined the association between isoflavones intake at the baseline and comorbidities at an 18-month follow-up. The baseline data collected included information on socio-demographics, health status, andunpometric measurements, and dietary intake using a dietary history questionnaire (DHQ). Each participant's cognitive function was evaluated using a mini mental state examination (MMSE), digit span, digit symbol, and geriatric depression scale (GDS). Results: The daily intake of total isoflavones, daidzein, and genistein were 19.1 ±19.7,11.7 ±12.3 and 7.6+8.1 mg/day, respectively. There was no significant association between isoflavones intake, and specific cognitive function including global, memory, executive functions, and depression. However, there was a significant association (p < 0.05) between isoflavones intake r=0.131 (95% CI: 0.064-0.199), daidzein intake r0.132 (95% CI: 0.064-0.199), and genistein intake ra0.129 (95% CI: 0.062-0.197) with memory (digit span) after adjustment for age, gender, educational level, and body mass index (11M1). No association was found between isoflavones intake and comorbidities (p > 0.05). Conclusion: This study found an association between isoflavones intake and memory function, but not with global cognitive, executive functions, depression, and comorbidities. There is a need to promote adequate isoflavones intake in view of its association with memory function.

KW - Cognitive function

KW - Comorbidities

KW - Isoflavones

KW - Older adults

KW - Phytoestrogen

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M3 - Article

VL - 22

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EP - 39

JO - Malaysian Journal of Nutrition

JF - Malaysian Journal of Nutrition

SN - 1394-035X

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