Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients

Batoul Sadat Haerian, Kheng Seang Lim, Hui Jan Tan, Elsa Hanifa Mejia Mohamed, Chong Tin Tan, Raymond Azman Ali, Chee Piau Wong, Sau Wei Wong, Haslyna Omar, Harun Roslan, Zahurin Mohamed

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Over-expression of P-glycoprotein, encoded by the ABCB1 gene, is proposed to be involved in resistance to antiepileptic drugs in about 30% of patients with epilepsy. Here, we investigated the possible association between ABCB1 polymorphisms and sodium valproate (VPA) treatment in Malaysian epilepsy patients. Genotypes were assessed in 249 drug-resistant and 256 drug-responsive Malaysian patients for C1236T, G2677T/A, and C 5T polymorphisms in the ABCB1 gene. No genotypes, alleles, or haplotypes were associated with the response to VPA in either the overall group or Chinese, Indian, and Malay subgroups. Our data suggest that C1236T, G2677T/A, and C3435T polymorphisms in the ABCB1 gene do not contribute to the response to VPA in patients with epilepsy.

Original languageEnglish
Pages (from-to)65-75
Number of pages11
JournalEpileptic Disorders
Volume13
Issue number1
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Valproic Acid
Epilepsy
Genotype
Genes
P-Glycoprotein
Therapeutics
Pharmaceutical Preparations
Anticonvulsants
Haplotypes
Alleles

Keywords

  • ABCB1
  • antiepileptic drug
  • epilepsy
  • P-glycoprotein
  • polymorphism
  • sodium valproate

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients. / Haerian, Batoul Sadat; Lim, Kheng Seang; Tan, Hui Jan; Mohamed, Elsa Hanifa Mejia; Tan, Chong Tin; Ali, Raymond Azman; Wong, Chee Piau; Wong, Sau Wei; Omar, Haslyna; Roslan, Harun; Mohamed, Zahurin.

In: Epileptic Disorders, Vol. 13, No. 1, 03.2011, p. 65-75.

Research output: Contribution to journalArticle

Haerian, Batoul Sadat ; Lim, Kheng Seang ; Tan, Hui Jan ; Mohamed, Elsa Hanifa Mejia ; Tan, Chong Tin ; Ali, Raymond Azman ; Wong, Chee Piau ; Wong, Sau Wei ; Omar, Haslyna ; Roslan, Harun ; Mohamed, Zahurin. / Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients. In: Epileptic Disorders. 2011 ; Vol. 13, No. 1. pp. 65-75.
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