Application of stem cells in tissue engineering for defense medicine

Chinedu Cletus Ude, Azizi Miskon, Ruszymah Idrus, Muhamad Bin Abu Bakar

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The dynamic nature of modern warfare, including threats and injuries faced by soldiers, necessitates the development of countermeasures that address a wide variety of injuries. Tissue engineering has emerged as a field with the potential to provide contemporary solutions. In this review, discussions focus on the applications of stem cells in tissue engineering to address health risks frequently faced by combatants at war. Human development depends intimately on stem cells, the mysterious precursor to every kind of cell in the body that, with proper instruction, can grow and differentiate into any new tissue or organ. Recent reports have suggested the greater therapeutic effects of the anti-inflammatory, trophic, paracrine and immune-modulatory functions associated with these cells, which induce them to restore normal healing and tissue regeneration by modulating immune reactions, regulating inflammation, and suppressing fibrosis. Therefore, the use of stem cells holds significant promise for the treatment of many battlefield injuries and their complications. These applications include the treatment of injuries to the skin, sensory organs, nervous system tissues, the musculoskeletal system, circulatory/pulmonary tissues and genitals/testicles and of acute radiation syndrome and the development of novel biosensors. The new research developments in these areas suggest that solutions are being developed to reduce critical consequences of wounds and exposures suffered in warfare. Current military applications of stem cell-based therapies are already saving the lives of soldiers who would have died in previous conflicts. Injuries that would have resulted in deaths previously now result in wounds today; similarly, today's permanent wounds may be reduced to tomorrow's bad memories with further advances in stem cell-based therapies.

Original languageEnglish
Article number7
JournalMilitary Medical Research
Volume5
Issue number1
DOIs
Publication statusPublished - 26 Feb 2018

Fingerprint

Tissue Engineering
Stem Cells
Medicine
Wounds and Injuries
Military Personnel
Cell- and Tissue-Based Therapy
Acute Radiation Syndrome
Nerve Tissue
Musculoskeletal System
Human Development
Biosensing Techniques
Therapeutic Uses
Nervous System
Testis
Regeneration
Fibrosis
Anti-Inflammatory Agents
Inflammation
Lung
Skin

Keywords

  • Defense medicine
  • Stem cells
  • Tissue engineering
  • War injuries

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Application of stem cells in tissue engineering for defense medicine. / Ude, Chinedu Cletus; Miskon, Azizi; Idrus, Ruszymah; Abu Bakar, Muhamad Bin.

In: Military Medical Research, Vol. 5, No. 1, 7, 26.02.2018.

Research output: Contribution to journalReview article

Ude, Chinedu Cletus ; Miskon, Azizi ; Idrus, Ruszymah ; Abu Bakar, Muhamad Bin. / Application of stem cells in tissue engineering for defense medicine. In: Military Medical Research. 2018 ; Vol. 5, No. 1.
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