Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents

R. Rafiee-Moghaddam, Jumat Salimon, M. J. Haron, H. Jahangirian, M. H S Ismail, L. Afsah-Hejri, N. Vafaei, Y. Tayefehchamani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hydroxamic acids, fatty hydroxamic acids and their metal complexes are known as compounds that have biological activity. They have been investigated as antimicrobial compounds and were applied as antibacterial and antifungal agents in pharmacy andpharmaceutical compounds. In this research, the methyl fatty hydroxamic acids (MFHAs) based on Jatrophacurcas seed oil and their metal complexes include the copper (II) methyl fatty hydroxamate (Cu-MFHs) and iron (III) methyl fatty hydroxamate (Fe- MFHs) were prepared and applied as anti microbial agents against the Escherichia coli (E. coli), Proteus vulgaris (P. vulgaris) andProteus mirabilis (P. mirabilis) as gramnegative bacteria; methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (S. epidermidis) as gram-positive bacteria; Candida parapsilosis (C. parapsilosis) and Candida Albicans (C. Albicans) as yeast family of fungi. The results showed that the antimicrobial activity of MFHAs, Cu-MFHs and Fe-MFHs increase while their amounts increase. Also metal complexation of MFHAs caused the anti microbial activity arise and this activity is higher for complexation by Cu (II) compared to that of Fe (III). Comparing antimicrobial activity of MFHAs, Cu-MFHs andFe-MFHs based on Jatrophacurcas seed oil with several antibiotic drugs such as ampicillin, chloramphenicol, gentamicin streptomycin, tetracycline and nystatin against the mentioned microbial showed that the Cu-MFHs andFe-MFHs have very strong antimicrobial activity.

Original languageEnglish
Pages (from-to)261-271
Number of pages11
JournalDigest Journal of Nanomaterials and Biostructures
Volume9
Issue number1
Publication statusPublished - 2014

Fingerprint

Jatropha
Hydroxamic Acids
Antimicrobial agents
Oilseeds
Coordination Complexes
fatty acids
Metal complexes
Anti-Infective Agents
Fatty acids
seeds
Seeds
Oils
Fatty Acids
oils
metals
staphylococcus
Candida
Complexation
bacteria
Bacteria

Keywords

  • Antimicrobial agent
  • Copper methyl fatty hydroxamate
  • Iron (III) methyl fatty hydroxamate
  • Jatrophacurcas seed oil
  • Methyl fatty hydroxamic acids

ASJC Scopus subject areas

  • Materials Science(all)
  • Biomedical Engineering
  • Physical and Theoretical Chemistry
  • Condensed Matter Physics
  • Structural Biology
  • Atomic and Molecular Physics, and Optics

Cite this

Rafiee-Moghaddam, R., Salimon, J., Haron, M. J., Jahangirian, H., Ismail, M. H. S., Afsah-Hejri, L., ... Tayefehchamani, Y. (2014). Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents. Digest Journal of Nanomaterials and Biostructures, 9(1), 261-271.

Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents. / Rafiee-Moghaddam, R.; Salimon, Jumat; Haron, M. J.; Jahangirian, H.; Ismail, M. H S; Afsah-Hejri, L.; Vafaei, N.; Tayefehchamani, Y.

In: Digest Journal of Nanomaterials and Biostructures, Vol. 9, No. 1, 2014, p. 261-271.

Research output: Contribution to journalArticle

Rafiee-Moghaddam, R, Salimon, J, Haron, MJ, Jahangirian, H, Ismail, MHS, Afsah-Hejri, L, Vafaei, N & Tayefehchamani, Y 2014, 'Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents', Digest Journal of Nanomaterials and Biostructures, vol. 9, no. 1, pp. 261-271.
Rafiee-Moghaddam, R. ; Salimon, Jumat ; Haron, M. J. ; Jahangirian, H. ; Ismail, M. H S ; Afsah-Hejri, L. ; Vafaei, N. ; Tayefehchamani, Y. / Application of methyl fatty hydroxamic acids based on Jatropha curcas seed oil and their metal complexes as anti microbial agents. In: Digest Journal of Nanomaterials and Biostructures. 2014 ; Vol. 9, No. 1. pp. 261-271.
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