Apparent bioavailability of isoflavones in urinary excretions of postmenopausal Malay women consuming tempeh compared with milk

Hasnah Haron, Amin Ismail, Suzana Shahar, Azrina Azlan, Loh Su Peng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Quantitation of isoflavones in humans is important to establish the benefits of these compounds to the populations. Urinary isoflavones are frequently used as a biomarker of isoflavone bioavailability from food or supplement since urine contains 100-fold higher concentrations of isoflavones. The objective of the present study was to determine and compare the urinary excretions of daidzein (DA), genistein (GE) and equol (EQ) in postmenopausal Malay women following the consumption of tempeh and milk in a calcium absorption study and to test the hypothesis that the excretion of isoflavones following consumption of tempeh maybe higher compared with milk. The amounts of DA (47.06 ± 4.18 μmol/h), GE (33.27 ± 3.71 μmol/h) and EQ (24.35 ± 4.34 μmol/h) excreted in urine following tempeh consumption were significantly higher (P < 0.05) compared with those in milk (3.51 ± 0.62 μmol/h DA, 2.79 ± 0.35 μmol/h GE and 0 μmol/h EQ). Almost all studied postmenopausal Malay women were able to excrete EQ following consumption of 240 g tempeh but only one subject can be classified as an equol producer. We concluded that most postmenopausal Malay women excreted DA, GE and EQ in their urine following tempeh consumption and the amount of the excreted isoflavones were higher compared with those in milk. However, further studies are needed to determine whether longer periods of time are required to capture EQ producers.

Original languageEnglish
Pages (from-to)642-650
Number of pages9
JournalInternational Journal of Food Sciences and Nutrition
Volume62
Issue number6
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Equol
tempeh
Soy Foods
Isoflavones
isoflavones
Biological Availability
bioavailability
Milk
daidzein
excretion
genistein
Genistein
milk
urine
Urine
Dietary Supplements
biomarkers
calcium
Biomarkers
Calcium

Keywords

  • Apparent bioavailability
  • isoflavones
  • Malay women
  • postmenopausal
  • tempeh
  • urine excretion

ASJC Scopus subject areas

  • Food Science

Cite this

Apparent bioavailability of isoflavones in urinary excretions of postmenopausal Malay women consuming tempeh compared with milk. / Haron, Hasnah; Ismail, Amin; Shahar, Suzana; Azlan, Azrina; Peng, Loh Su.

In: International Journal of Food Sciences and Nutrition, Vol. 62, No. 6, 09.2011, p. 642-650.

Research output: Contribution to journalArticle

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