Apoptosis changes and SA-beta galactosidase expression in stress-induced premature senescence (SIPS) model of human skin fibroblasts.

N. Abdul Rahim, Suzana Makpol, Chua Kien Hui, Yasmin Anum Mohd Yusof, G. M. Top, W. Z Wan Ngah

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Abstract

Stress-induced premature senescence (SIPS) model is in vitro model of cellular aging. In this study, apoptosis was evaluated in SIPS model and in replicative senescent fibroblasts. We also compared the activity of senescence-associated beta-galactosidase (SA-beta gal) as a biomarker of cellular aging. Our results suggested that SIPS model and senescent fibroblasts might share similar mechanism of aging and apoptosis pathway.

Original languageEnglish
Pages (from-to)71-72
Number of pages2
JournalThe Medical journal of Malaysia
Volume63 Suppl A
Publication statusPublished - Jul 2008

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beta-Galactosidase
Fibroblasts
Apoptosis
Skin
Cell Aging
Biomarkers

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Apoptosis changes and SA-beta galactosidase expression in stress-induced premature senescence (SIPS) model of human skin fibroblasts.",
abstract = "Stress-induced premature senescence (SIPS) model is in vitro model of cellular aging. In this study, apoptosis was evaluated in SIPS model and in replicative senescent fibroblasts. We also compared the activity of senescence-associated beta-galactosidase (SA-beta gal) as a biomarker of cellular aging. Our results suggested that SIPS model and senescent fibroblasts might share similar mechanism of aging and apoptosis pathway.",
author = "{Abdul Rahim}, N. and Suzana Makpol and {Kien Hui}, Chua and {Mohd Yusof}, {Yasmin Anum} and Top, {G. M.} and Ngah, {W. Z Wan}",
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T1 - Apoptosis changes and SA-beta galactosidase expression in stress-induced premature senescence (SIPS) model of human skin fibroblasts.

AU - Abdul Rahim, N.

AU - Makpol, Suzana

AU - Kien Hui, Chua

AU - Mohd Yusof, Yasmin Anum

AU - Top, G. M.

AU - Ngah, W. Z Wan

PY - 2008/7

Y1 - 2008/7

N2 - Stress-induced premature senescence (SIPS) model is in vitro model of cellular aging. In this study, apoptosis was evaluated in SIPS model and in replicative senescent fibroblasts. We also compared the activity of senescence-associated beta-galactosidase (SA-beta gal) as a biomarker of cellular aging. Our results suggested that SIPS model and senescent fibroblasts might share similar mechanism of aging and apoptosis pathway.

AB - Stress-induced premature senescence (SIPS) model is in vitro model of cellular aging. In this study, apoptosis was evaluated in SIPS model and in replicative senescent fibroblasts. We also compared the activity of senescence-associated beta-galactosidase (SA-beta gal) as a biomarker of cellular aging. Our results suggested that SIPS model and senescent fibroblasts might share similar mechanism of aging and apoptosis pathway.

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M3 - Article

VL - 63 Suppl A

SP - 71

EP - 72

JO - Medical Journal of Malaysia

JF - Medical Journal of Malaysia

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