Potensi afrodisiak lunasia amara ke atas tikus jantan teraruh diabetes

Translated title of the contribution: Aphrodisiac potential of lunasia amara on diabetic-Induced male rats

Nor Raidah Rahmat, Amira Kamalrudin, Mohd Shazrul Fazry Sa`Ariwijaya, Mahanem Mat Noor

Research output: Contribution to journalArticle

Abstract

Accumulating evidence shows that diabetes mellitus alters the production of testosterone and contributes to the reduction of libido in male. Formerly, no study has been conducted on the effect of Lunasia amara on sexual activity in diabetic-induced male rats. Therefore, present study looked into the aphrodisiac potential of L. amara on diabetic-induced male rats. Four groups of diabetic-induced male rats were given L. amara aqueous extract (250 and 500 mg/kg body weight), 500 mg/kg metformin and distilled water, respectively. A group of control rats was given distilled water. Treatments were given for 30 days to investigate the effect of L. amara aqueous extract on libido, serum testosterone level, body weight, morphometry of testis, cauda epididymis and antioxidant enzymes activity in diabetic-induced rats in comparison to control. The result showed diabetic-induced rats treated with both doses of L. amara extract exhibit significant reduction (p<0.05) in libido, testosterone level, testis antioxidant enzymes activity (glutathione peroxidase, catalase and superoxide dismutase) compared to control. On the other hand, the administration of L. amara did not affect body weight, morphometry of testis and cauda epididymis of diabetic-induced rats compared to normal control. This findings suggested that L. amara at doses 250 and 500 mg/kg body weight is incapable of improving sexual activity in diabetic-induced male rats.

Original languageMalay
Pages (from-to)1109-1115
Number of pages7
JournalSains Malaysiana
Volume47
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

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Aphrodisiacs
Libido
Body Weight
Testosterone
Testis
Epididymis
Sexual Behavior
Antioxidants
Water
Metformin
Enzymes
Glutathione Peroxidase
Catalase
Superoxide Dismutase
Diabetes Mellitus
Control Groups

ASJC Scopus subject areas

  • General

Cite this

Potensi afrodisiak lunasia amara ke atas tikus jantan teraruh diabetes. / Rahmat, Nor Raidah; Kamalrudin, Amira; Sa`Ariwijaya, Mohd Shazrul Fazry; Mat Noor, Mahanem.

In: Sains Malaysiana, Vol. 47, No. 6, 01.06.2018, p. 1109-1115.

Research output: Contribution to journalArticle

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