Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica

A. M. Ali, N. H. Ismail, Muhammad Mukram Mohamed Mackeen, L. S. Yazan, S. M. Mohamed, A. S H Ho, N. H. Lajis

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

2-Formyl-1-hydroxyanthraquinone, along with ten other known anthraquinones (1-hydroxy-2-methylanthraquinone, nordamnacanthal, damnacanthal, lucidin-ω-methyl ether, rubiadin, rubiadin-1-methyl ether, soranjidiol, morindone, morindone-5-methyl ether and alizarin-1-methyl ether), isolated from the roots of Morinda elliptica, were assayed for anti-HIV, cytotoxic and antimicrobial activites. Only damnacanthal showed moderate activity against HIV. It was cytotoxic towards the MCF-7 (breast carcinoma) and CEM-SS (T-lymphoblastic leukaemia) cell line. Nordamnacanthal was very cytotoxic against the CEM-SS cell lines. Other anthraquinones that showed strong cytotoxicity towards the cell lines tested were lucidin ω-methyl ether (CEM-SS and MCF-7) and rubiadin (CEM-SS). Three anthraquinones viz., nordamnacanthal, damnacanthal and morindone, were found to have strong antimicrobial activity.

Original languageEnglish
Pages (from-to)298-301
Number of pages4
JournalPharmaceutical Biology
Volume38
Issue number4
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Morinda
Methyl Ethers
Anthraquinones
anthraquinones
Antiviral Agents
ethers
anti-infective agents
Cells
Cell Line
HIV
cell lines
Cytotoxicity
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Ethers
alizarin
lymphocytic leukemia
Breast Neoplasms
breast neoplasms
cytotoxicity
morindone

Keywords

  • Anthraquinones
  • Antimicrobial
  • Antiviral
  • Cytotoxic
  • Morinda elliptica

ASJC Scopus subject areas

  • Plant Science
  • Medical Laboratory Technology
  • Clinical Biochemistry
  • Pharmacology

Cite this

Ali, A. M., Ismail, N. H., Mohamed Mackeen, M. M., Yazan, L. S., Mohamed, S. M., Ho, A. S. H., & Lajis, N. H. (2000). Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica. Pharmaceutical Biology, 38(4), 298-301.

Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica. / Ali, A. M.; Ismail, N. H.; Mohamed Mackeen, Muhammad Mukram; Yazan, L. S.; Mohamed, S. M.; Ho, A. S H; Lajis, N. H.

In: Pharmaceutical Biology, Vol. 38, No. 4, 2000, p. 298-301.

Research output: Contribution to journalArticle

Ali, AM, Ismail, NH, Mohamed Mackeen, MM, Yazan, LS, Mohamed, SM, Ho, ASH & Lajis, NH 2000, 'Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica', Pharmaceutical Biology, vol. 38, no. 4, pp. 298-301.
Ali, A. M. ; Ismail, N. H. ; Mohamed Mackeen, Muhammad Mukram ; Yazan, L. S. ; Mohamed, S. M. ; Ho, A. S H ; Lajis, N. H. / Antiviral, cyototoxic and antimicrobial activities of anthraquinones isolated from the roots of Morinda elliptica. In: Pharmaceutical Biology. 2000 ; Vol. 38, No. 4. pp. 298-301.
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