Antiproliferative properties and antioxidant activity of various types of Strobilanthes crispus tea

Mohd Fadzelly Abu Bakar, Arnida Hani Teh, Asmah Rahmat, Fauziah Othman, Normah Hashim, Sharida Fakurazi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Regarding to the promising pharmacotherapeutic properties of Strobilanthes crispus (Acanthaceae) plant, we report here, the development of nutraceutical herbal tea from S. crispus young and old leaves and evaluate the potential antiproliferative properties and antioxidant activity in vitro. Unfermented and fermented tea (Camellia sinensis) preparation was applied for development of S. crispus tea. Antiproliferative properties of S. crispus tea extracts were determined by the microculture tetrazolium salt (MTT) assay against human breast cancer cell lines (hormone dependent, MCF-7, non-hormone dependent, MDA-MB-231). The results showed that S. crispus tea only inhibit the proliferation of human hormone dependent breast cancer cell lines (MCF-7) but not the non-hormone dependent breast cancer cell lines (MDA-MB-231). The antioxidant activity was determined using FRAP (Ferric Reducing/Antioxidant Power) and DPPH free radical scavenging assay. The results showed that the hot water extract of S. crispus tea showed high antioxidant activity especially S. crispus unfermented tea from old leaves. But the tea from the leaves of C. sinensis displayed better antioxidant activity.

Original languageEnglish
Pages (from-to)152-158
Number of pages7
JournalInternational Journal of Cancer Research
Volume2
Issue number2
DOIs
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

Tea
Antioxidants
Camellia sinensis
Breast Neoplasms
Cell Line
Acanthaceae
Hormones
Tetrazolium Salts
Plant Development
Dietary Supplements
Free Radicals
Water

Keywords

  • Antioxidant
  • Antiproliferative
  • DPPH free radical scavenging
  • FRAP
  • MTT
  • Strobilanthes crispus
  • Tea

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Antiproliferative properties and antioxidant activity of various types of Strobilanthes crispus tea. / Abu Bakar, Mohd Fadzelly; Teh, Arnida Hani; Rahmat, Asmah; Othman, Fauziah; Hashim, Normah; Fakurazi, Sharida.

In: International Journal of Cancer Research, Vol. 2, No. 2, 2006, p. 152-158.

Research output: Contribution to journalArticle

Abu Bakar, Mohd Fadzelly ; Teh, Arnida Hani ; Rahmat, Asmah ; Othman, Fauziah ; Hashim, Normah ; Fakurazi, Sharida. / Antiproliferative properties and antioxidant activity of various types of Strobilanthes crispus tea. In: International Journal of Cancer Research. 2006 ; Vol. 2, No. 2. pp. 152-158.
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