Antiplatelet aggregation and platelet activating factor (PAF) receptor antagonistic activities of the essential oils of five Goniothalamus species

Bushra Abdulkarim Moharam, Ibrahim Jantan, Fasihuddin Bin Ahmad, Juriyati Jalil

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Nine essential oils, hydrodistilled from different parts of five Goniothalamus species (G. velutinus Airy-Shaw, G. woodii Merr., G. clemensii Ban, G. tapis Miq. and G. tapisoides Mat Salleh) were evaluated for their ability to inhibit platelet aggregation in human whole blood using an electrical impedance method and their inhibitory effects on platelet activating factor (PAF) receptor binding with rabbit platelets using 3H-PAF as a ligand. The chemical composition of the oils was analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The bark oil of G. velutinus was the most effective sample as it inhibited both arachidonic acid (AA) and ADP-induced platelet aggregation with IC50 values of 93.6 and 87.7 μg/mL, respectively. Among the studied oils, the bark oils of G. clemensii, G. woodii, G. velutinus and the root oil of G. tapis showed significant inhibitory effects on PAF receptor binding, with IC50 values ranging from 3.5 to 10.5 μg/mL. The strong PAF antagonistic activity of the active oils is related to their high contents of sesquiterpenes and sesquiterpenoids, and the individual components in the oils could possibly produce a synergistic effect in the overall antiplatelet activity of the oils.

Original languageEnglish
Pages (from-to)5124-5138
Number of pages15
JournalMolecules
Volume15
Issue number8
DOIs
Publication statusPublished - Aug 2010

Fingerprint

Goniothalamus
Volatile Oils
platelets
Oils
Agglomeration
oils
Platelets
Platelet Activating Factor
Platelet Aggregation
Gas chromatography
gas chromatography
Inhibitory Concentration 50
Acoustic impedance
platelet activating factor receptor
Sesquiterpenes
adenosine diphosphate
Electric Impedance
rabbits
Arachidonic Acid
Gas Chromatography

Keywords

  • Antiplatelet aggregation
  • Essential oils
  • GC-MS
  • Goniothalamus species
  • Platelet activating factor (PAF) antagonists

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Antiplatelet aggregation and platelet activating factor (PAF) receptor antagonistic activities of the essential oils of five Goniothalamus species. / Moharam, Bushra Abdulkarim; Jantan, Ibrahim; Ahmad, Fasihuddin Bin; Jalil, Juriyati.

In: Molecules, Vol. 15, No. 8, 08.2010, p. 5124-5138.

Research output: Contribution to journalArticle

Moharam, Bushra Abdulkarim ; Jantan, Ibrahim ; Ahmad, Fasihuddin Bin ; Jalil, Juriyati. / Antiplatelet aggregation and platelet activating factor (PAF) receptor antagonistic activities of the essential oils of five Goniothalamus species. In: Molecules. 2010 ; Vol. 15, No. 8. pp. 5124-5138.
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