Antiplatelet aggregation activity of compounds isolated from Guttiferae species in human whole blood

Ibrahim Jantan, Yusyila Harlina Mohd Yasin, Juriyati Jalil, Shahnaz Murad, Muhammad Sum Idris

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Twenty compounds isolated from Calophyllum inophyllum L., C. inophylloides King, Garcinia opaca King, G. bancana Miq., and G. parvifolia Miq. (Guttiferae) were evaluated for their ability to inhibit platelet aggregation in human whole blood induced by arachidonic acid (AA), collagen, and adenosine diphosphate (ADP). The compounds inhibited platelet aggregation in a dose-dependent manner. Among the compounds tested, 2-(3-methylbut-2-enyl)-1,3,5-trihydroxyxanthone and 2-(3-methylbut-2-enyl)-1,3,5,6- tetrahydroxyxanthone showed strong inhibitory activity on platelet aggregation induced by AA with IC50 values of 115.9 and 113.0μM, respectively. Rubraxanthone showed inhibitory activity against aggregation caused by the three inducers, and was the most effective antiplatelet compound against collagen-induced platelet aggregation with an IC50 value of 47.0μM. Macluraxanthone, GB-1a, pyranoamentoflavone, and a neoflavonoid showed selective inhibitory activity on platelet aggregation induced by ADP.

Original languageEnglish
Pages (from-to)1090-1095
Number of pages6
JournalPharmaceutical Biology
Volume47
Issue number11
DOIs
Publication statusPublished - Nov 2009

Fingerprint

Platelet Aggregation
Arachidonic Acid
Adenosine Diphosphate
Inhibitory Concentration 50
Calophyllum
Collagen
Garcinia

Keywords

  • Antiplatelet aggregation
  • Guttiferae
  • Human whole blood

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Molecular Medicine

Cite this

Antiplatelet aggregation activity of compounds isolated from Guttiferae species in human whole blood. / Jantan, Ibrahim; Mohd Yasin, Yusyila Harlina; Jalil, Juriyati; Murad, Shahnaz; Idris, Muhammad Sum.

In: Pharmaceutical Biology, Vol. 47, No. 11, 11.2009, p. 1090-1095.

Research output: Contribution to journalArticle

Jantan, Ibrahim ; Mohd Yasin, Yusyila Harlina ; Jalil, Juriyati ; Murad, Shahnaz ; Idris, Muhammad Sum. / Antiplatelet aggregation activity of compounds isolated from Guttiferae species in human whole blood. In: Pharmaceutical Biology. 2009 ; Vol. 47, No. 11. pp. 1090-1095.
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