Antiplatelet activity of aporphine and phenanthrenoid alkaloids from Aromadendron elegans blume

Ibrahim Jantan, Salwa M. Raweh, Yusyila Harlina Mohd Yasin, Shahnaz Murad

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Six aporphine and one phenanthrenoid alkaloids isolated from Aromadendron elegans Blume were investigated for their ability to inhibit arachidonic acid (AA), collagen and ADP induced platelet aggregation in human whole blood. The antiplatelet activity of the compounds was measured in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Of the compounds tested, (-)-N-acetylnornuciferine, (-)-N-acetylanonaine and 1-(N-acetyl-N- methylamino)ethyl-3,4,6-trimethoxy-7-hydroxyphenanthrene showed strong inhibition on platelet aggregation caused by all three inducers. (-)-N-acetylanonaine was the most effective antiplatelet compound as it inhibited both arachidonic acid, collagen and ADP-induced platelet aggregation with IC50 values of 66.1, 95.1 and 80.6 μM, respectively.

Original languageEnglish
Pages (from-to)493-496
Number of pages4
JournalPhytotherapy Research
Volume20
Issue number6
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Platelets
Platelet Aggregation
Alkaloids
Agglomeration
Arachidonic Acid
Adenosine Diphosphate
Blood
Collagen
Acoustic impedance
Electric Impedance
Inhibitory Concentration 50
aporphine

Keywords

  • Antiplatelet aggregation activity
  • Aporphine alkaloids
  • Arachidonic acid
  • Aromadendron elegans
  • Human whole blood

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Antiplatelet activity of aporphine and phenanthrenoid alkaloids from Aromadendron elegans blume. / Jantan, Ibrahim; Raweh, Salwa M.; Yasin, Yusyila Harlina Mohd; Murad, Shahnaz.

In: Phytotherapy Research, Vol. 20, No. 6, 06.2006, p. 493-496.

Research output: Contribution to journalArticle

Jantan, Ibrahim ; Raweh, Salwa M. ; Yasin, Yusyila Harlina Mohd ; Murad, Shahnaz. / Antiplatelet activity of aporphine and phenanthrenoid alkaloids from Aromadendron elegans blume. In: Phytotherapy Research. 2006 ; Vol. 20, No. 6. pp. 493-496.
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