Antioxidants effects of platinum nanoparticles: A potential alternative treatment to lung diseases

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Imbalance oxidative status occurs when oxidative stress is higher in the body due to the production of reactive oxygen species. Thus, antioxidants are needed to counteract the production of free radicals. Reoccurrence of oxidative stress in the lung cells will eventually lead to inflammation and edema. This will result to a severe prognosis of lung diseases. Our interest is to populate certain mechanisms that can be activated during this process by reversing the oxidative stress status. Platinum nanoparticles (PtNPs) have been suggested as one of the powerful antioxidants that can quench free radicals. The mechanistic pathway may involve Protein Kinase C, which correlates well with the expression of the Epithelial Sodium Channel (ENaC). ENaC plays an important role in sodium uptake thus stimulate lung liquid clearance. The failure of lung clearance will interrupt gaseous exchange thus eventually lead to death. This review will discuss on the antioxidant properties of PtNPs as well as the underlying mechanism of PKC and ENaC in maintaining the oxidative status in the lung cells.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalJournal of Applied Pharmaceutical Science
Volume5
Issue number7
DOIs
Publication statusPublished - 2015

Fingerprint

Platinum
Nanoparticles
Lung Diseases
Antioxidants
Lung
Oxidative Stress
Free Radicals
Epithelial Sodium Channels
Protein Kinase C
Reactive Oxygen Species
Edema
Sodium
Inflammation

Keywords

  • Antioxidants
  • Epithelial sodium channel (ENAc)
  • Platinum nanoparticles
  • Reactive oxygen species (ROS)

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine (miscellaneous)
  • Pharmacology (medical)

Cite this

@article{b5e1bfdfc4fd48fea7659c1d5ab506d4,
title = "Antioxidants effects of platinum nanoparticles: A potential alternative treatment to lung diseases",
abstract = "Imbalance oxidative status occurs when oxidative stress is higher in the body due to the production of reactive oxygen species. Thus, antioxidants are needed to counteract the production of free radicals. Reoccurrence of oxidative stress in the lung cells will eventually lead to inflammation and edema. This will result to a severe prognosis of lung diseases. Our interest is to populate certain mechanisms that can be activated during this process by reversing the oxidative stress status. Platinum nanoparticles (PtNPs) have been suggested as one of the powerful antioxidants that can quench free radicals. The mechanistic pathway may involve Protein Kinase C, which correlates well with the expression of the Epithelial Sodium Channel (ENaC). ENaC plays an important role in sodium uptake thus stimulate lung liquid clearance. The failure of lung clearance will interrupt gaseous exchange thus eventually lead to death. This review will discuss on the antioxidant properties of PtNPs as well as the underlying mechanism of PKC and ENaC in maintaining the oxidative status in the lung cells.",
keywords = "Antioxidants, Epithelial sodium channel (ENAc), Platinum nanoparticles, Reactive oxygen species (ROS)",
author = "Fatimah Yusof and Ismail, {Noor Akmal Shareela}",
year = "2015",
doi = "10.7324/JAPS.2015.50722",
language = "English",
volume = "5",
pages = "140--145",
journal = "Journal of Applied Pharmaceutical Science",
issn = "2231-3354",
publisher = "MediPoeia",
number = "7",

}

TY - JOUR

T1 - Antioxidants effects of platinum nanoparticles

T2 - A potential alternative treatment to lung diseases

AU - Yusof, Fatimah

AU - Ismail, Noor Akmal Shareela

PY - 2015

Y1 - 2015

N2 - Imbalance oxidative status occurs when oxidative stress is higher in the body due to the production of reactive oxygen species. Thus, antioxidants are needed to counteract the production of free radicals. Reoccurrence of oxidative stress in the lung cells will eventually lead to inflammation and edema. This will result to a severe prognosis of lung diseases. Our interest is to populate certain mechanisms that can be activated during this process by reversing the oxidative stress status. Platinum nanoparticles (PtNPs) have been suggested as one of the powerful antioxidants that can quench free radicals. The mechanistic pathway may involve Protein Kinase C, which correlates well with the expression of the Epithelial Sodium Channel (ENaC). ENaC plays an important role in sodium uptake thus stimulate lung liquid clearance. The failure of lung clearance will interrupt gaseous exchange thus eventually lead to death. This review will discuss on the antioxidant properties of PtNPs as well as the underlying mechanism of PKC and ENaC in maintaining the oxidative status in the lung cells.

AB - Imbalance oxidative status occurs when oxidative stress is higher in the body due to the production of reactive oxygen species. Thus, antioxidants are needed to counteract the production of free radicals. Reoccurrence of oxidative stress in the lung cells will eventually lead to inflammation and edema. This will result to a severe prognosis of lung diseases. Our interest is to populate certain mechanisms that can be activated during this process by reversing the oxidative stress status. Platinum nanoparticles (PtNPs) have been suggested as one of the powerful antioxidants that can quench free radicals. The mechanistic pathway may involve Protein Kinase C, which correlates well with the expression of the Epithelial Sodium Channel (ENaC). ENaC plays an important role in sodium uptake thus stimulate lung liquid clearance. The failure of lung clearance will interrupt gaseous exchange thus eventually lead to death. This review will discuss on the antioxidant properties of PtNPs as well as the underlying mechanism of PKC and ENaC in maintaining the oxidative status in the lung cells.

KW - Antioxidants

KW - Epithelial sodium channel (ENAc)

KW - Platinum nanoparticles

KW - Reactive oxygen species (ROS)

UR - http://www.scopus.com/inward/record.url?scp=84938897882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938897882&partnerID=8YFLogxK

U2 - 10.7324/JAPS.2015.50722

DO - 10.7324/JAPS.2015.50722

M3 - Article

AN - SCOPUS:84938897882

VL - 5

SP - 140

EP - 145

JO - Journal of Applied Pharmaceutical Science

JF - Journal of Applied Pharmaceutical Science

SN - 2231-3354

IS - 7

ER -