Antioxidant modulation in restoring mitochondrial function in neurodegeneration

Aslina Pahrudin Arrozi, Wan Zurinah Wan Ngah, Yasmin Anum Mohd Yusof, Mohd Hanafi Ahmad Damanhuri, Suzana Makpol

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are the leading causes of disability associated with neurodegeneration worldwide. These diseases are influenced by multiple genetic and environmental factors and share similar mechanisms as both are characterized by accumulation and aggregation of misfolded proteins–amyloid-beta (Aβ) in AD and α-synuclein in PD. Over the past decade, increasing evidence has shown that mitochondrial dysfunction and the generation of reactive oxygen species (ROS) are involved in the pathology of these diseases, and the contributions of these defects to the cellular and molecular changes that eventually cause neuronal death have been explored. Using mitochondrial protective agents, such as antioxidants, to combat ROS provides a new strategy for neurodegenerative treatment. In this review, we highlight the potential of multiple types of antioxidants, including vitamins, phytochemicals, fatty acids and minerals, as well as synthetic antioxidants specifically targeting the mitochondria, which can restore mitochondrial function, in the treatment of neurodegenerative disorders at both the pre-clinical and clinical stages by focusing on AD and PD.

Original languageEnglish
Pages (from-to)218-235
Number of pages18
JournalInternational Journal of Neuroscience
Volume127
Issue number3
DOIs
Publication statusPublished - 4 Mar 2017

Fingerprint

Parkinson Disease
Alzheimer Disease
Antioxidants
Reactive Oxygen Species
Synucleins
Protective Agents
Phytochemicals
Vitamins
Neurodegenerative Diseases
Minerals
Cause of Death
Mitochondria
Fatty Acids
Pathology

Keywords

  • antioxidants
  • misfolded proteins
  • mitochondrial dysfunction
  • neurodegeneration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Antioxidant modulation in restoring mitochondrial function in neurodegeneration. / Pahrudin Arrozi, Aslina; Wan Ngah, Wan Zurinah; Mohd Yusof, Yasmin Anum; Ahmad Damanhuri, Mohd Hanafi; Makpol, Suzana.

In: International Journal of Neuroscience, Vol. 127, No. 3, 04.03.2017, p. 218-235.

Research output: Contribution to journalReview article

Pahrudin Arrozi, Aslina ; Wan Ngah, Wan Zurinah ; Mohd Yusof, Yasmin Anum ; Ahmad Damanhuri, Mohd Hanafi ; Makpol, Suzana. / Antioxidant modulation in restoring mitochondrial function in neurodegeneration. In: International Journal of Neuroscience. 2017 ; Vol. 127, No. 3. pp. 218-235.
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