Abstract
Alzheimer's disease (AD) and Parkinson's disease (PD) are the leading causes of disability associated with neurodegeneration worldwide. These diseases are influenced by multiple genetic and environmental factors and share similar mechanisms as both are characterized by accumulation and aggregation of misfolded proteins–amyloid-beta (Aβ) in AD and α-synuclein in PD. Over the past decade, increasing evidence has shown that mitochondrial dysfunction and the generation of reactive oxygen species (ROS) are involved in the pathology of these diseases, and the contributions of these defects to the cellular and molecular changes that eventually cause neuronal death have been explored. Using mitochondrial protective agents, such as antioxidants, to combat ROS provides a new strategy for neurodegenerative treatment. In this review, we highlight the potential of multiple types of antioxidants, including vitamins, phytochemicals, fatty acids and minerals, as well as synthetic antioxidants specifically targeting the mitochondria, which can restore mitochondrial function, in the treatment of neurodegenerative disorders at both the pre-clinical and clinical stages by focusing on AD and PD.
| Original language | English |
|---|---|
| Pages (from-to) | 218-235 |
| Number of pages | 18 |
| Journal | International Journal of Neuroscience |
| Volume | 127 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 4 Mar 2017 |
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Keywords
- antioxidants
- misfolded proteins
- mitochondrial dysfunction
- neurodegeneration
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Antioxidant modulation in restoring mitochondrial function in neurodegeneration. / Pahrudin Arrozi, Aslina; Wan Ngah, Wan Zurinah; Mohd Yusof, Yasmin Anum; Ahmad Damanhuri, Mohd Hanafi; Makpol, Suzana.
In: International Journal of Neuroscience, Vol. 127, No. 3, 04.03.2017, p. 218-235.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Antioxidant modulation in restoring mitochondrial function in neurodegeneration
AU - Pahrudin Arrozi, Aslina
AU - Wan Ngah, Wan Zurinah
AU - Mohd Yusof, Yasmin Anum
AU - Ahmad Damanhuri, Mohd Hanafi
AU - Makpol, Suzana
PY - 2017/3/4
Y1 - 2017/3/4
N2 - Alzheimer's disease (AD) and Parkinson's disease (PD) are the leading causes of disability associated with neurodegeneration worldwide. These diseases are influenced by multiple genetic and environmental factors and share similar mechanisms as both are characterized by accumulation and aggregation of misfolded proteins–amyloid-beta (Aβ) in AD and α-synuclein in PD. Over the past decade, increasing evidence has shown that mitochondrial dysfunction and the generation of reactive oxygen species (ROS) are involved in the pathology of these diseases, and the contributions of these defects to the cellular and molecular changes that eventually cause neuronal death have been explored. Using mitochondrial protective agents, such as antioxidants, to combat ROS provides a new strategy for neurodegenerative treatment. In this review, we highlight the potential of multiple types of antioxidants, including vitamins, phytochemicals, fatty acids and minerals, as well as synthetic antioxidants specifically targeting the mitochondria, which can restore mitochondrial function, in the treatment of neurodegenerative disorders at both the pre-clinical and clinical stages by focusing on AD and PD.
AB - Alzheimer's disease (AD) and Parkinson's disease (PD) are the leading causes of disability associated with neurodegeneration worldwide. These diseases are influenced by multiple genetic and environmental factors and share similar mechanisms as both are characterized by accumulation and aggregation of misfolded proteins–amyloid-beta (Aβ) in AD and α-synuclein in PD. Over the past decade, increasing evidence has shown that mitochondrial dysfunction and the generation of reactive oxygen species (ROS) are involved in the pathology of these diseases, and the contributions of these defects to the cellular and molecular changes that eventually cause neuronal death have been explored. Using mitochondrial protective agents, such as antioxidants, to combat ROS provides a new strategy for neurodegenerative treatment. In this review, we highlight the potential of multiple types of antioxidants, including vitamins, phytochemicals, fatty acids and minerals, as well as synthetic antioxidants specifically targeting the mitochondria, which can restore mitochondrial function, in the treatment of neurodegenerative disorders at both the pre-clinical and clinical stages by focusing on AD and PD.
KW - antioxidants
KW - misfolded proteins
KW - mitochondrial dysfunction
KW - neurodegeneration
UR - http://www.scopus.com/inward/record.url?scp=85009164378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009164378&partnerID=8YFLogxK
U2 - 10.1080/00207454.2016.1178261
DO - 10.1080/00207454.2016.1178261
M3 - Review article
C2 - 27074540
AN - SCOPUS:85009164378
VL - 127
SP - 218
EP - 235
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
SN - 0020-7454
IS - 3
ER -